In three empirical studies we examined how people reason about prior convictions in child abuse cases. We tested whether the disclosure of similar prior convictions prompts a mental representation or an additive probative value (Criminal Justice Act, 2003). Asymmetrical use of similar priors were observed in three studies. A pilot study showed that disclosure of a second prior did not contribute a weight equivalent to that of the first disclosure. Study 1 showed jurors did not see left-handed evidence (i.e. matching (...) victim bruising) as more indicative of guilt than right-handedness unless a prior conviction was present, and the presence of priors suppressed the generation of alternative possibilities indicative of innocence. Study 2 showed that disclosure did not decrease community ratings of reoffending propensity and dangerousness as much as a similar prior conviction increased them. We consider the results in the context of a new psychological theory of prior conviction bias and the consequences for the implementation of Section 100 of the Criminal Justice Act (2003). (shrink)

DNA evidence is one of the most significant modern advances in the search for truth since the cross examination, but its format as a random-match-probability makes it difficult for people to assign an appropriate probative value (Koehler, 2001). While Frequentist theories propose that the presentation of the match as a frequency rather than a probability facilitates more accurate assessment (e.g., Slovic et al., 2000), Exemplar-Cueing Theory predicts that the subjective weight assigned may be affected by the frequency or probability format, (...) and how easily examples of the event, i.e., ‘exemplars’, are generated from linguistic cues that frame the match in light of further evidence (Koehler & Macchi, 2004). This paper presents two juror research studies to examine the difficulties that jurors have in assigning appropriate probative value to DNA evidence when contradictory evidence is presented. Study 1 showed that refuting evidence significantly reduced guilt judgments when exemplars were linguistically cued, even when the probability match and the refuting evidence had the same objective probative value. Moreover, qualitative reason for judgment responses revealed that interpreting refuting evidence was found to be complex and not necessarily reductive; refutation was found indicative of innocence or guilt depending on whether exemplars have been cued or not. Study 2 showed that the introduction of judges’ directions to linguistically cue exemplars, did not increase the impact of refuting evidence beyond its objective probative value, but less guilty verdicts were returned when jurors were instructed to consider all possible explanations of the evidence. The results are discussed in light of contradictory frequentist and exemplar-cueing theoretical positions, and their real-world consequences. (shrink)

Two main cognitive theories predict that people find refuting evidence that falsifies their theorising difficult, if not impossible to consider, even though such reasoning may be pivotal to grounding their everyday thoughts in reality (i.e., Poletiek, 1996; Klayman & Ha, 1987). In the classic 2-4-6 number sequence task devised by psychologists to test such reasoning skills in a simulated environment – people fail the test more often than not. In the 2-4-6 task participants try to discover what rule the number (...) triple 2-4-6 conforms to. The rule is ‘ascending numbers’, but it is tricky to discover this rule. Participants tend to generate hypotheses with the properties of the 2-4-6 triple, for example, ‘even numbers ascending in twos’. They must search for evidence to test whether their hypothesis is the rule. But experimental evidence has shown that they tend to generate confirming triples that they expect to be consistent with their hypothesis rather than inconsistent falsifying triples. Counter to the two main hypothesis testing theories this paper demonstrates that falsification is possible in five 2-4-6 task experiments when participants consider an Imaginary Participant’s hypothesis. Experiment 1 and 2 show that competition with an opponent hypothesis tester facilitates falsification. Experiments 3 to 5 show that the consideration of an alternative hypothesis helps this falsification of hypotheses lead to rule discovery. The implications of the results for theories of hypothesis testing and reasoning are discussed. (shrink)

Intended and merely foreseen consequences: The psychology of the ‘cause or allow’ offence. A short report for the Socio-Legal Community on ESRC Grant RES-000-22-3114.

Many theories in philosophy, law, and psychology, make no distinction in meaning between causing and enabling conditions. Yet, psychologically people readily make such distinctions each day. In this paper we report three experiments, showing that individuals distinguish between causes and enabling conditions in brief descriptions of wrongful outcomes. Respondents rate actions that bring about outcomes as causes, and actions that make possible the causal relation as enablers. Likewise, causers (as opposed to enablers) are rated as more responsible for the outcome, (...) as liable to longer prison sentences, and as liable to pay higher fines. Moreover, the more actors involved, the more blame volume there is psychologically to be apportioned between them. The implication is that theories and the law in practice, both criminal and civil, may dangerously mismatch the intuitions of those to whom they are supposed to apply. The findings are discussed in light of contemporary psychological theories of how people reason about cause. -/- The paper presents the extended findings supplementary to the conference paper: Frosch, C. A., Johnson-Laird, P. N., Cowley, M. (2007). Don’t blame me your Honor, I’m only the enabler. Proceedings of the Twenty–Ninth Annual Conference of the Cognitive Science Society, p. 1755, Mahweh, N. J: Erlbaum. Nashville, USA. *Main findings now cited in the Oxford Handbook of Causal Reasoning. (shrink)

The purpose of this paper is to provide a detailed technical protocol analysis of chess masters' evaluative expertise, paying particular attention to the analysis of the structure of their memory process in evaluating foreseen possibilities in games of dynamic equilibrium. The paper has two purposes. First, to publish a results chapter from my DPhil thesis (in revised journal article form) attending to the measurement of foresight in chess masters' evaluation process, testing alternative theories of cognitive expertise in the domain of (...) chess; and second to provide a subset of the technical graphical analysis that corresponds to that measurement to preserve this protocol analysis for access in the academic domain for future studies of expert memory and foresight (e.g., Ericsson & Simon, 1993). The step-by-step protocol analysis consists of: (i) an introduction to foresight cognition as hypothesis testing, (ii) a theoretical review in the domain of chess masters' expertise according to the theoretical frameworks in that field purporting hypotheses relevant to chess masters' evaluative skill processes, and (iii) summary tables and non-parametric statistical analysis corroborating chunking theory frameworks of expert cognition (e.g., DeGroot, 1965; Newell & Simon, 1972; Gobet, 1998; Gobet et al., 2004), and refuting the alternative search-evaluation models (e.g., Holding & Reynolds, 1982). Moreover, the journal article espouses the preservation of the traditional protocol analysis method core to the field of expert cognition (DeGroot, 1969; Kotov, 1971). The full protocol analysis can be found in monograph form here on my SSRN profile in ‘The role of falsification in hypothesis testing’. It takes the form of a specialist population study (e.g., detailed case study work; Luria, 1987). Thus the outline consists of a short introduction, a theoretical methodological review discussing protocol analysis methods for specialist population studies in cognition (with particular attention to the preservation of protocol analysis methods for chess studies in cognition and expert memory/ with a fresh angle on the foresight process), and the full set of protocol analyses with corresponding problem behaviour graphs. A subset of the main results has been published elsewhere (e.g., Cowley & Byrne, 2004; Cowley 2006), receiving scientific and scientific journalistic acclaim (e.g., Nature Online News 2004). (shrink)

Falsification may demarcate science from non-science as the rational way to test the truth of hypotheses. But experimental evidence from studies of reasoning shows that people often find falsification difficult. We suggest that domain expertise may facilitate falsification. We consider new experimental data about chess experts’ hypothesis testing. The results show that chess masters were readily able to falsify their plans. They generated move sequences that falsified their plans more readily than novice players, who tended to confirm their plans. The (...) finding that experts in a domain are more likely to falsify their hypotheses has important implications for the debate about human rationality. (shrink)

This paper presents empirical findings from a set of reasoning and mock jury studies presented at the Experimental Psychology Oxford Seminar Series (2010) and the King's Bench Chambers KBW Barristers Seminar Series (2010). The presentation asks the following questions and presents empirical answers using the Lenses of Evidence Framework (Cowley & Colyer, 2010; see also van Koppen & Wagenaar, 1993): -/- Why is mental representation important for psychology? -/- Why is mental representation important for evidence law? -/- Lens 1: The (...) self representation - Key findings -/- Lens 2: The expert representation - Key findings -/- Lens 3: The anchor representation - Key findings -/- Conclusions & Future directions. -/- The series of research essentially explores how people represent evidence in mind and presents key findings now cited in the following literatures: Philosophy of Science, Cognitive Expertise, Behavioural Economics, Cognitive Science, Psychology and Public Policy, & Causation and the Law. (shrink)

There are two competing theoretical frameworks with which cognitive sciences examines how people reason. These frameworks are broadly categorized into logic and probability. This paper reports two applied experiments to test which framework explains better how people reason about evidence in criminal cases. Logical frameworks predict that people derive conclusions from the presented evidence to endorse an absolute value of certainty such as ‘guilty’ or ‘not guilty’ (e.g., Johnson-Laird, 1999). But probabilistic frameworks predict that people derive conclusions from the presented (...) evidence in order that they may use knowledge of prior instances to endorse a conclusion of guilt which varies in certainty (e.g., Tenenbaum, Griffiths, & Kemp, 2006). Experiment 1 showed that reasoning about evidence of prior instances, such as disclosed prior convictions, affected participants’ underlying ratings of guilt. Participants’ guilt ratings increased in certainty according to the number of disclosed prior convictions. Experiment 2 showed that participants’ reasoning about evidence of prior convictions and some forensic evidence tended to lead participants to endorse biased ‘guilty’ verdicts when rationally the evidence does not prove guilt. Both results are predicted by probabilistic frameworks. The paper considers the implications for logical and probabilistic frameworks for reasoning in the real world. (shrink)

Can people consistently attempt to falsify, that is, search for refuting evidence, when testing the truth of hypotheses? Experimental evidence indicates that people tend to search for confirming evidence. We report two novel experiments that show that people can consistently falsify when it is the only helpful strategy. Experiment 1 showed that participants readily falsified somebody else’s hypothesis. Their task was to test a hypothesis belonging to an ‘imaginary participant’ and they knew it was a low quality hypothesis. Experiment 2 (...) showed that participants were able to falsify a low quality hypothesis belonging to an imaginary participant more readily than their own low quality hypothesis. The results have important implications for theories of hypothesis testing and human rationality. (shrink)

According to the mental model theory, causes and enablers differ in meaning, and therefore in their logical consequences (Goldvarg & Johnson-Laird, 2001). They are consistent with different possibilities. Recent psychological studies have argued to the contrary, and suggested that linguistic cues guide this distinction (Kuhnmünch & Beller, 2005). The issue is important because neither British nor American law recognizes this distinction (e.g., Roberts & Zuckerman, 2004). Yet, in our view, it is central to human conceptions of causality. Hence, in two (...) experiments, we examined our participants’ ability to distinguish between causes and enablers in scenarios describing the actions of two agents and a subsequent outcome, e.g.: ‘Mary threw a lighted cigarette into a bush. Just as the cigarette was going out, Laura deliberately threw petrol on it. The resulting fire burnt down her neighbor’s house.’ Here Mary enabled the fire to occur, whereas Laura caused the fire to occur. (shrink)

This summary note series outlines legal empirical approaches to the study of juries and jury decision-making behaviour for undergraduate students of sociology, criminology and legal systems, and forensic psychology. The note series is divided into two lectures. The first lecture attends to the background relevant to the historical rise of juries and socio-legal methodologies used to understand jury behaviour. The second lecture attends to questions surrounding jury competence, classic studies illustrative of juror bias, and a critical comparison of juries to (...) legal alternatives not reliant on jury deliberation for judicial process. Where appropriate the note series indicates key readings relevant to each core component of the note series, for students to develop their understanding in self-study time. (shrink)

This notebook presents an introductory overview to the cognitive perspective on the psychology of human behaviour for social science students. Starting with an introduction to cognitive developmental theories of how babies reason, the overview then moves to discuss how children develop into better thinkers. Adult theories of cognition are subsequently outlined and critically evaluated. -/- A chronology of topics include: the rise of 'this thing we call cognition', Piaget's theory of cognitive development and its evaluation, problem space theory, and theories (...) of mental representation in adult thought examining, amongst other types of thinking and reasoning, deduction and induction and an evaluation of mental representation theories. (shrink)

The Repugnant Conclusion served an important purpose in catalyzing and inspiring the pioneering stage of population ethics research. We believe, however, that the Repugnant Conclusion now receives too much focus. Avoiding the Repugnant Conclusion should no longer be the central goal driving population ethics research, despite its importance to the fundamental accomplishments of the existing literature.

In this position paper, we describe a number of methodological and philosophical challenges that arose within our interdisciplinary Digital Humanities project CatVis, which is a collaboration between applied geometric algorithms and visualization researchers, data scientists working at OCLC, and philosophers who have a strong interest in the methodological foundations of visualization research. The challenges we describe concern aspects of one single epistemic need: that of methodologically securing (an increase in) trust in visualizations. We discuss the lack of ground truths in (...) the (digital) humanities and argue that trust in visualizations requires that we evaluate visualizations on the basis of ground truths that humanities scholars themselves create. We further argue that trust in visualizations requires that a visualization provides provable guarantees on the faithfulness of the visual representation and that we must clearly communicate to the users which part of the visualization can be trusted and how much. Finally, we discuss transparency and accessibility in visualization research and provide measures for securing transparency and accessibility. (shrink)

This paper focuses on extant approaches to counteract the consumption of fake news online. Proponents of structural approaches suggest that our proneness to consuming fake news could only be reduced by reshaping the architecture of online environments. Proponents of educational approaches suggest that fake news consumers should be empowered to improve their epistemic agency. In this paper, we address a question that is relevant to this debate: namely, whether fake news consumers commit mistakes for which they can be criticized and (...) that they could easily avoid by reforming their doxastic conduct. Proponents of structural approaches, like R. Rini and B. Millar, have defended in different ways a negative answer to this question. In this paper, we criticize their views and suggest that individual users could improve on their epistemic practice by widening their information diet. (shrink)

This paper addresses a largely neglected question in ongoing debates over disagreement: what is the relation, if any, between disagreements involving credences and disagreements involving outright beliefs? The first part of the paper offers some desiderata for an adequate account of credal and full disagreement. The second part of the paper argues that both phenomena can be subsumed under a schematic definition which goes as follows: A and B disagree if and only if the accuracy conditions of A's doxastic attitude (...) are such that, if they were fulfilled, this would ipso facto make B's doxastic attitude inaccurate, or vice-versa. (shrink)

A review of Tiziana Andina's The Philosophy of Art: The Question of Definition: From Hegel to Post-Dantian Theories (Bloomsbury 2013).

According to Steiner (1998), in contemporary physics new important discoveries are often obtained by means of strategies which rely on purely formal mathematical considerations. In such discoveries, mathematics seems to have a peculiar and controversial role, which apparently cannot be accounted for by means of standard methodological criteria. M. Gell-Mann and Y. Ne׳eman׳s prediction of the Ω− particle is usually considered a typical example of application of this kind of strategy. According to Bangu (2008), this prediction is apparently based on (...) the employment of a highly controversial principle—what he calls the “reification principle”. Bangu himself takes this principle to be methodologically unjustifiable, but still indispensable to make the prediction logically sound. In the present paper I will offer a new reconstruction of the reasoning that led to this prediction. By means of this reconstruction, I will show that we do not need to postulate any “reificatory” role of mathematics in contemporary physics and I will contextually clarify the representative and heuristic role of mathematics in science. (shrink)

Philosophers have cataloged a range of genealogical methods by which different sorts of normative conclusions can be established. Although such methods provide diverging ways of pursuing genealogical inquiry, they typically converge in eschewing historiographic methodology, in favor of a uniquely philosophical approach. In contrast, one genealogist who drew on historiographic methodology is Michel Foucault. This article presents the motivations and advantages of Foucault's genealogical use of such a methodology. It advances two mains claims. First, that Foucault's early 1970s work employs (...) a distinct genealogical method, which borrows from contemporary historiographic models of explanation to expand the range of objects that are proper to genealogical accounts of historical change. I demonstrate how Foucault modifies two central commitments of Nietzsche by broadening the dimensions of genealogical inquiry and explanation. Second, that historical method has normative relevance for genealogy, insofar as different historiographic choices can lead to different normative conclusions. I motivate this second claim by explaining how Foucault's multidimensional genealogical method expands both (a) the range of objects that are subject to evaluative assessment, and (b) the set of possible prescriptive recommendations that follow from such assessment. (shrink)

In this paper I argue that Miranda Fricker’s account of blame in “What’s the Point of Blame? A Paradigm Based Explanation” can assist in explaining why cancel culture is ultimately unproductive. In particular, the phenomenon of cancel culture possesses pathological forms of blame. There are three specific pathologies outlined by Fricker that can be observed in cancel culture. They are as follows: cancel culture does not leave room for people to learn from their mistakes, it does not express its blame (...) in the proper ethical register, and cancel culture allows for blame to fester and spread. In the first half of my paper, I will lay out the distinct aspects of Fricker’s paper that relate to cancel culture and a definition of the term cancel culture. In the second half, I will explore the real-life cancelation of actor Lea Michele so as to validate the presence of cancel culture in our society today. Furthermore, I will expand on three of Fricker’s pathologies that are present in cancel culture and refute a counter argument people may pose who are supportive of cancel culture. (shrink)

The Psychological Society of Ireland’s (PSI) response to the call from the United Nations (UN) Committee on the Rights of the Child: Draft General Comment No. 26 Calls for comment on the draft general comment on children’s rights and the environment with a special focus on climate change III. ‘Specific rights of the Convention as they relate to the environment’, B. The right to the highest attainable standard of health (art. 24), 27. … children’s current and anticipated psychosocial, emotional and (...) mental health problems and suffering caused by environmental harm. The PSI wishes to express sincere thanks to the Society’s Special Interest Group in Human Rights and Psychology, particularly Dr Michelle Cowley-Cunningham, Dr Elaine Rogers, and Ms Alexis Carey, who coordinated the following response on behalf of the Society. 1. Environmental degradation, loss of biodiversity, and climate change impact children’s human rights and present a serious threat to future generations’ enjoyment of human rights. Distressingly, 1.7 million children lose their lives annually as a result of avoidable environmental impacts, while millions more are impacted by disease, displaced from their homes and miss out on receiving education1. The PSI Special Interest Group in Human Rights and Psychology (SIGHRP) is grateful to the Committee on the Rights of the Child for this opportunity to submit a stakeholder comment in advance of the drafting of the Draft General Comment No. 26. SIGHRP is appreciative of the work of the Committee in monitoring the implementation of the Convention on the Rights of the Child (UNCRC) and welcomes the Committee's stakeholder call for ideas to aid the development of policies, both domestically and internationally, to address critical climate change issues. Specifically, SIGHRP welcomes the opportunity to comment on the connection between child and adolescent mental health and human rights obligations, and advocates for policies and initiatives to address this issue in the context of climate change. (shrink)

While the immediate aim of Walter Benjamin’s famous essay, “Critique of Violence,” is to provide a critique of legal violence, commentators typically interpret it as providing a further critique of state violence. However, this interpretation often receives no further argument, and it remains unclear whether Benjamin’s essay may prove analytically relevant for a critique of state violence today. This paper argues that the “Critique” proves thusly relevant, but only on condition that it is developed in two directions. The first direction (...) is conceptual, and consists in an explanation of the necessary relationship between states and violence. This explanation is found by appealing to a concept not cited in Benjamin’s text, but which, I argue, remains its implicit basis: sovereignty. According to this conceptual development, state violence is the necessary result of the state's attempt to maintain its sovereign law at the expense of emancipatory struggles to generate non-sovereign law. The second direction is genealogical, and consists in destabilizing the modern belief that justice is best served through the judicial channels of a sovereign state. Here I employ Michel Foucault’s genealogical research to demonstrate the historical contingency of state justice and, by extension, the possibility of a justice beyond the state. (shrink)

[First paragraphs: This essay takes its practical orientation from my experiences as a member of a philosophy reading group on death row at Riverbend Maximum Security Penitentiary in Nashville, Tennessee. Its theoretical orientation comes from W. E. B. Du Bois’ lecture-turned-essay, “Criteria of Negro Art,” which argues that the realm of aesthetics is vitally important in the war against racial discrimination in the United States. And since, according to Michele Alexander’s critically-acclaimed The New Jim Crow: Mass Incarceration in the Age (...) of Colorblindness, the prison system should be the primary front today in this war, my essay’s ultimate aim is t/o articulate a new criterion of the present-day “Negro” art being created by a prison population that is still overwhelmingly constituted by persons of color. In my first section, I will show how Du Bois’ insights in “Criteria of Negro Art” remain relevant today, especially in the prison context, and argue that it is thus appropriate for my new criterion to be shaped by his distinctive conception of “propaganda.” In my second section, through a close reading of two texts by Michel Foucault (the pivotal thinker of modern imprisonment), I will flesh out this new criterion, “self-torsion,” defined as the effect of prisoners’ attempts at self-care within a prison system that distorts those attempts into further exploitation of both prisoners and the outside world that imprisons them. And my final section, in an attempt to illustrate this new criterion’s efficacy as a form of propagandistic resistance to contemporary racism, will deploy self-torsion as a critique of two artworks created by imprisoned members of my reading group at Riverbend penitentiary. (shrink)

This paper questions the use of new technologies as tools of modern surveillance in order to: (a) advance the research done by Michel Foucault on panoptic techniques of surveillance and dominance; and (b) give new insights on the way we use these new surveillance technologies in violation of democratic principles and legal norms. Furthermore, it questions Foucault’s statements on the expansion of Bentham’s Panopticon scheme as a universal model of modern-day democratic institutions. Therefore the purpose of this paper is to (...) (c) shed new light on the various ways the deployment of new technologies reinforces the Panopticon model, and (d) conduct an analysis of the effects produced by the emerging modes of surveillance that empower various new mechanisms of domination and control of individuals. This research paper seeks to (e) examine to what extent technology influences the course of our social, political and behavioral changes; and to propose devices for (f) evaluation and transformation of democratic institutions and practices that rely on the use of modern communication tools and technologies. Our cities have become a new kind of technologically driven Panopticon and this model has achieved perfection as increasingly fragmented, disseminated and ubiquitous device of power and dominance. (shrink)

continent. 1.1 : 3-13. / 0/ – Introduction I want to propose, as a trajectory into the philosophically weird, an absurd theoretical claim and pursue it, or perhaps more accurately, construct it as I point to it, collecting the ground work behind me like the Perpetual Train from China Mieville's Iron Council which puts down track as it moves reclaiming it along the way. The strange trajectory is the following: Kant's critical philosophy and much of continental philosophy which has followed, (...) has been a defense against horror and madness. Kant's prohibition on speculative metaphysics such as dogmatic metaphysics and transcendental realism, on thinking beyond the imposition of transcendental and moral constraints, has been challenged by numerous figures proceeding him. One of the more interesting critiques of Kant comes from the mad black Deleuzianism of Nick Land stating, “Kant’s critical philosophy is the most elaborate fit of panic in the history of the Earth.” And while Alain Badiou would certainly be opposed to the libidinal investments of Land's Deleuzo-Guattarian thought, he is likewise critical of Kant's normative thought-bureaucracies: Kant is the one author for whom I cannot feel any kinship. Everything in him exasperates me, above all his legalism—always asking Quid Juris? Or ‘Haven’t you crossed the limit?’—combined, as in today’s United States, with a religiosity that is all the more dismal in that it is both omnipresent and vague. The critical machinery he set up has enduringly poisoned philosophy, while giving great succour to the academy, which loves nothing more than to rap the knuckles of the overambitious [….] That is how I understand the truth of Monique David-Menard’s reflections on the properly psychotic origins of Kantianism. I am persuaded that the whole of the critical enterprise is set up to to shield against the tempting symptom represented by the seer Swedenborg, or against ‘diseases of the head’, as Kant puts it. An entire nexus of the limits of reason and philosophy are set up here, namely that the critical philosophy not only defends thought from madness, philosophy from madness, and philosophy from itself, but that philosophy following the advent of the critical enterprise philosophy becomes auto-vampiric; feeding on itself to support the academy. Following Francois Laruelle's non-philosophical indictment of philosophy, we could go one step further and say that philosophy operates on the material of what is philosophizable and not the material of the external world. [1] Beyond this, the Kantian scheme of nestling human thinking between our limited empirical powers and transcendental guarantees of categorical coherence, forms of thinking which stretch beyond either appear illegitimate, thereby liquefying both pre-critical metaphysics and the ravings of the mad in the same critical acid. In rejecting the Kantian apparatus we are left with two entities – an unsure relation of thought to reality where thought is susceptible to internal and external breakdown and a reality with an uncertain sense of stability. These two strands will be pursued, against the sane-seal of post-Kantian philosophy by engaging the work of weird fiction authors H.P. Lovecraft and Thomas Ligotti. The absolute inhumanism of the formers universe will be used to describe a Shoggothic Materialism while the dream worlds of the latter will articulate the mad speculation of a Ventriloquil Idealism. But first we must address the relation of philosophy to madness as well as philosophy to weird fiction. /1/ – Philosophy and Madness There is nothing that the madness of men invents which is not either nature made manifest or nature restored. Michel Foucault. Madness and Civilization. The moment I doubt whether an event that I recall actually took place, I bring the suspicion of madness upon myself: unless I am uncertain as to whether it was not a mere dream. Arthur Schopenhauer. The World as Will and Idea, Vol. 3. Madness is commonly thought of as moving through several well known cultural-historical shifts from madness as a demonic or otherwise theological force, to rationalization, to medicalization psychiatric and otherwise. Foucault's Madness and Civilization is well known for orientating madness as a form of exclusionary social control which operated by demarcating madness from reason. Yet Foucault points to the possibility of madness as the necessity of nature at least prior to the crushing weight of the church. Kant’s philosophy as a response to madness is grounded by his humanizing of madness itself. As Adrian Johnston points out in the early pages of Time Driven pre-Kantian madness meant humans were seized by demonic or angelic forces whereas Kantian madness became one of being too human. Madness becomes internalized, the external demonic forces become flaws of the individual mind. Foucault argues that, while madness is de-demonized it is also dehumanized during the Renaissance, as madmen become creatures neither diabolic nor totally human reduced to the zero degree of humanity. It is immediately clear why for Kant, speculative metaphysics must be curbed – with the problem of internal madness and without the external safeguards of transcendental conditions, there is nothing to formally separate the speculative capacities for metaphysical diagnosis from the mad ramblings of the insane mind – both equally fall outside the realm of practicality and quotidian experience. David-Menard's work is particularly useful in diagnosing the relation of thought and madness in Kant's texts. David-Menard argues that in Kant's relatively unknown “An Essay on the Maladies of the Mind” as well as his later discussion of the Seer of Swedenborg, that Kant formulates madness primarily in terms of sensory upheaval or other hallucinatory theaters. She writes: “madness is an organization of thought. It is made possible by the ambiguity of the normal relation between the imaginary and the perceived, whether this pertains to the order of sensation or to the relations between our ideas” Kant's fascination with the Seer forces Kant between the pincers of “aesthetic reconciliation” – namely melancholic withdrawal – and “a philosophical invention” – namely the critical project. Deleuze and Guattari's schizoanalysis is a combination and reversal of Kant's split, where an aesthetic over engagement with the world entails prolific conceptual invention. Their embrace of madness, however, is of course itself conceptual despite all their rhizomatic maneuvers. Though they move with the energy of madness, Deleuze and Guattari save the capacity of thought from the fangs of insanity by imbuing materiality itself with the capacity for thought. Or, as Ray Brassier puts it, “Deleuze insists, it is necessary to absolutize the immanence of this world in such a way as to dissolve the transcendent disjunction between things as we know them and as they are in themselves”. That is, whereas Kant relied on the faculty of judgment to divide representation from objectivity Deleuze attempts to flatten the whole economy beneath the juggernaut of ontological univocity. Speculation, as a particularly useful form of madness, might fall close to Deleuze and Guattari’s shaping of philosophy into a concept producing machine but is different in that it is potentially self destructive – less reliant on the stability of its own concepts and more adherent to exposing a particular horrifying swath of reality. Speculative madness is always a potential disaster in that it acknowledges little more than its own speculative power with the hope that the gibbering of at least a handful of hysterical brains will be useful. Pre-critical metaphysics amounts to madness, though this may be because the world itself is mad while new attempts at speculative metaphysics, at post-Kantian pre-critical metaphysics, are well aware of our own madness. Without the sobriety of the principle of sufficient reason we have a world of neon madness: “we would have to conceive what our life would be if all the movements of the earth, all the noises of the earth, all the smells, the tastes, all the light – of the earth and elsewhere, came to us in a moment, in an instant – like an atrocious screaming tumult of things”. Speculative thought may be participatory in the screaming tumult of the world or, worse yet, may produce its spectral double. Against theology or reason or simply commonsense, the speculative becomes heretical. Speculation, as the cognitive extension of the horrorific sublime should be met with melancholic detachment. Whereas Kant's theoretical invention, or productivity of thought, is self -sabotaging, since the advent of the critical project is a productivity of thought which then delimits the engine of thought at large either in dogmatic gestures or non-systematizable empirical wondrousness. The former is celebrated by the fiction of Thomas Ligotti whereas the latter is espoused by the tales of H.P. Lovecraft. /2/ – Weird Fiction and Philosophy. Supernatural horror, in all its eerie constructions, enables a reader to taste treats inconsistent with his personal welfare. Thomas Ligotti Songs of a Dead Dreamer. I choose weird stories because they suit my inclination best—one of my strongest and most persistent wishes being to achieve,momentarily, the illusion of some strange suspension or violation of the galling limitations of time, space, and natural law which forever imprison us and frustrate our curiosity about the infinite cosmic spaces beyond the radius of our sight and analysis H.P. Lovecraft. “Notes on Writing Weird Fiction” Lovecraft states that his creation of a story is to suspend natural law yet, at the same time, he indexes the tenuousness of such laws, suggesting the vast possibilities of the cosmic. The tension that Lovecraft sets up between his own fictions and the universe or nature is reproduced within his fictions in the common theme of the unreliable narrator; unreliable precisely because they are either mad or what they have witnessed questions the bounds of material reality. In “The Call of Cthulhu” Lovecraft writes: The most merciful thing in the world, I think, is the inability of the human mind to correlate all its contents. We live on a placid island of ignorance in the midst of black seas of infinity, and it was not meant that we should voyage far. The sciences, each straining in its own direction, have hitherto harmed us little; but some day the piecing together of dissociated knowledge will open up such terrifying vistas of reality, and of our frightful position therein, that we shall either go mad from the revelation or flee from the deadly light into the peace and safety of a new dark age. Despite Lovecraft's invocations of illusion, he is not claiming that his fantastic creations such as the Old Ones are supernatural but, following Joshi, are only ever supernormal. One can immediately see that instead of nullifying realism Lovecraft in fact opens up the real to an unbearable degree. In various letters and non-fictional statements Lovecraft espoused strictly materialist tenets, ones which he borrowed from Hugh Elliot namely the uniformity of law, the denial of teleology and the denial of non-material existence. Lovecraft seeks to explore the possibilities of such a universe by piling horror upon horror until the fragile brain which attempts to grasp it fractures. This may be why philosophy has largely ignored weird fiction – while Deleuze and Guattari mark the turn towards weird fiction and Lovecraft in particular, with the precursors to speculative realism as well as contemporary related thinkers have begun to view Lovecraft as making philosophical contributions. Lovecraft's own relation to philosophy is largely critical while celebrating Nietzsche and Schopenhauer. This relationship of Lovecraft to philosophy and philosophy to Lovecraft is coupled with Lovecraft's habit of mercilessly destroying the philosopher and the figure of the academic more generally in his work, a destruction which is both an epistemological destruction and an ontological destruction. Thomas Ligotti's weird fiction which he has designated as a kind of “confrontational escapism” might be best described in the following quote from one of his shortstories, “The human phenomenon is but the sum of densely coiled layers of illusion each of which winds itself on the supreme insanity. That there are persons of any kind when all there can be is mindless mirrors laughing and screaming as they parade about in an endless dream”. Whereas Lovecraft's weirdness draws predominantly from the abyssal depths of the uncharted universe, Ligotti's existential horror focuses on the awful proliferation of meaningless surfaces that is, the banal and every day function of representation. In an interview, Ligotti states: We don't even know what the world is like except through our sense organs, which are provably inadequate. It's no less the case with our brains. Our whole lives are motored along by forces we cannot know and perceptions that are faulty. We sometimes hear people say that they're not feeling themselves. Well, who or what do they feel like then? This is not to say that Ligotti sees nothing beneath the surface but that there is only darkness or blackness behind it, whether that surface is on the cosmological level or the personal. By addressing the implicit and explicit philosophical issues in Ligotti's work we will see that his nightmarish take on reality is a form of malevolent idealism, an idealism which is grounded in a real, albeit dark and obscure materiality. If Ligotti's horrors ultimately circle around mad perceptions which degrade the subject, it takes aim at the vast majority of the focus of continental philosophy. While Lovecraft's acidic materialism clearly assaults any romantic concept of being from the outside, Ligotti attacks consciousness from the inside: Just a little doubt slipped into the mind, a little trickle of suspicion in the bloodstream, and all those eyes of ours, one by one, open up to the world and see its horror [...] Not even the solar brilliance of a summer day will harbor you from horror. For horror eats the light and digests it into darkness. Clearly, the weird fiction of Lovecraft and Ligotti amount to a anti-anthrocentric onslaught against the ramparts of correlationist continental philosophy. /3/ – Shoggothic Materialism or the Formless Formless protoplasm able to mock and reflect all forms and organs and processes—viscous agglutinations of bubbling cells—rubbery fifteen-foot spheroids infinitely plastic and ductile—slaves of suggestion, builders of cities—more and more sullen, more and more intelligent, more and more amphibious, more and more imitative—Great God! What madness made even those blasphemous Old Ones willing to use and to carve such things? H.P. Lovecraft. “At the Mountains of Madness” On the other hand, affirming that the universe resembles nothing and is only formless amounts to saying that the universe is something like a spider or spit. Georges Bataille. “Formless”. The Shoggoths feature most prominently in H.P. Lovecraft's shortstory “At the Mountains of Madness” where they are described in the following manner: It was a terrible, indescribable thing vaster than any subway train – a shapeless congeries of protoplasmic bubbles, faintly self -luminous, and with myriads of temporary eyes forming and un-forming as pustules of greenish light all over the tunnel-filling front that bore down upon us, crushing the frantic penguins and slithering over the glistening floor that it and its kind had swept so evilly free of all litter. The term is a litmus test for materialism itself as the Shoggoth is an amorphous creature. The Shoggoths were living digging machines bio engineered by the Elder Things, and their protoplasmic bodies being formed into various tools by their hypnotic powers. The Shoggoths eventually became self aware and rose up against their masters in an ultimately failed rebellion. After the Elder Ones retreated into the oceans leaving the Shoggoths to roam the frozen wastes of the Antarctic. The onto-genesis of the Shoggoths and their gross materiality, index the horrifyingly deep time of the earth a concept near and dear to Lovecraft's formulation of horror as well as the fear of intelligences far beyond, and far before, the ascent of humankind on earth and elsewhere. The sickly amorphous nature of the Shoggoths invade materialism at large, where while materiality is unmistakably real ie not discursive, psychological, or otherwise overly subjectivist, it questions the relation of materialism to life. As Eugene Thacker writes: The Shoggoths or Elder Things do not even share the same reality with the human beings who encounter them—and yet this encounter takes place, though in a strange no-place that is neither quite that of the phenomenal world of the human subject or the noumenal world of an external reality. Amorphous yet definitively material beings are a constant in Lovecraft's tales. In his tale “The Dream-Quest of Unknown Kadatth” Lovecraft describes Azathoth as, “that shocking final peril which gibbers unmentionably outside the ordered universe,” that, “last amorphous blight of nethermost confusion which blashphemes and bubbles at the centre of all infinity,” who, “gnaws hungrily in inconceivable, unlighted chambers beyond time”. Azathoth's name may have multiple origins but the most striking is the alchemy term azoth which is both a cohesive agent and a acidic creation pointing back to the generative and the decayed. The indistinction of generation and degradation materially mirrors the blur between the natural and the unnatural as well as life and non-life. Lovecraft speaks of the tension between the natural and the unnatural is his short story “The Unnameable.” He writes, “if the psychic emanations of human creatures be grotesque distortions, what coherent representation could express or portray so gibbous and infamous a nebulousity as the spectre of a malign, chaotic perversion, itself a morbid blasphemy against Nature?”. Lovecraft explores exactly the tension outlined at the beginning of this chapter, between life and thought. At the end of his short tale Lovecraft compounds the problem as the unnameable is described as “a gelatin—a slime—yet it had shapes, a thousand shapes of horror beyond all memory”. Deleuze suggests that becoming-animal is operative throughout Lovecraft's work, where narrators feel themselves reeling at their becoming non-human or of being the anomalous or of becoming atomized. Following Eugene Thacker however, it may be far more accurate to say that Lovecraft's tales exhibit not a becoming-animal but a becoming-creature. Where the monstrous breaks the purportedly fixed laws of nature, the creature is far more ontologically ambiguous. The nameless thing is an altogether different horizon for thought. The creature is either less than animal or more than animal – its becoming is too strange for animal categories and indexes the slow march of thought towards the bizarre. This strangeness is, as aways, some indefinite swirling in the category of immanence and becoming. Bataille begins “The Labyrinth” with the assertion that being, to continue to be, is becoming. More becoming means more being hence the assertion that Bataille's barking dog is more than the sponge. This would mean that the Shoggotth is altogether too much being, too much material in the materialism. Bataille suggests that there is an immanence between the eater and the eaten, across the species and never within them. That is, despite the chaotic storm of immanence there must remain some capacity to distinguish the gradients of becoming without reliance upon, or at least total dependence upon, the powers of intellection to parse the universe into recognizable bits, properly digestible factoids. That is, if we undo Deleuze's aforementioned valorization of sense which, for his variation of materialism, performed the work of the transcendental, but refuse to reinstate Kant's transcendental disjunction between thing and appearance, then it must be a quality of becoming-as-being itself which can account for the discernible nature of things by sense. In an interview with Peter Gratton, Jane Bennett formulates the problem thusly: What is this strange systematicity proper to a world of Becoming? What, for example, initiates this congealing that will undo itself? Is it possible to identify phases within this formativity, plateaus of differentiation? If so, do the phases/plateaus follow a temporal sequence? Or, does the process of formation inside Becoming require us to theorize a non-chronological kind of time? I think that your student’s question: “How can we account for something like iterable structures in an assemblage theory?” is exactly the right question. Philosophy has erred too far on the side of the subject in the subject-object relation and has furthermore, lost the very weirdness of the non-human. Beyond this, the madness of thought need not override. /4/ - Ventriloquial Idealism or the Externality of Thought My aim is the opposite of Lovecraft's. He had an appreciation for natural scenery on earth and wanted to reach beyond the visible in the universe. I have no appreciation for natural scenery and want the objective universe to be a reflection of a character. Thomas Ligotti. “Devotees of Decay and Desolation.” Unless life is a dream, nothing makes sense. For as a reality, it is a rank failure [….] Horror is more real than we are. Thomas Ligotti. “Professor Nobody's Little Lectures on Supernatural Horror”. Thomas Ligotti's tales are rife with mannequins, puppets, and other brainless entities which of replace the valorized subject of philosophy – that of the free thinking human being. His tales such as “The Dream of the Manikin” aim to destroy the rootedness of consciousness. James Trafford has connected the anti-egoism of Ligotti to Thomas Metzinger – where the self is at best an illusion and we plead desperately for someone else to acknowledge that we are real. Trafford has stated it thus, “Life is played out as an inescapable puppet show, an endless dream in which the puppets are generally unaware that they are trapped within a mesmeric dance of whose mechanisms they know nothing and over which they have no control”. An absolute materialism, for Ligotti, implies an alienation of the idea which leads to a ventriloquil idealism. As Ligotti notes in an interview, “the fiasco and nightmare of existence, the particular fiasco and nightmare of human existence, the sense that people are puppets of powers they cannot comprehend, etc.” And then further elaborates that,“[a]ssuming that anything has to exist, my perfect world would be one in which everyone has experienced the annulment of his or her ego. That is, our consciousness of ourselves as unique individuals would entirely disappear”. The externality of the idea leads to the unfortunate consequence of consciousness eating at itself through horror which, for Ligotti, is more real than reality and goes beyond horror-as-affect. Beyond this, taking together with the unreality of life and the ventriloquizing of subjectivity, Ligotti's thought becomes an idealism in which thought itself is alien and ultimately horrifying. The role of human thought and the relation of non-relation of horror to thought is not completely clear in Ligotti's The Conspiracy Against the Human Race. Ligotti argues in his The Conspiracy Against the Human Race,that the advent of thought is a mistake of nature and that horror is being in the sense that horror results from knowing too much. Yet, at the same time, Ligotti seems to suggest that thought separates us from nature whereas, for Lovecraft, thought is far less privileged – mind is just another manifestation of the vital principal, it is just another materialization of energy. In his brilliant “Prospects for Post-Copernican Dogmatism” Iain Grant rallies against the negative definition of dogmatism and the transcendental, and suggests that negatively defining both over-focuses on conditions of access and subjectivism at the expense of the real or nature. With Schelling, who is Grant's champion against the subjectivist bastions of both Fichte and Kant, Ligotti's idealism could be taken as a transcendental realism following from an ontological realism. Yet the transcendental status of Ligotti's thought move towards a treatment of the transcendental which may threaten to leave beyond its realist ground. Ligotti states: Belief in the supernatural is only superstition. That said, a sense of the supernatural, as Conrad evidenced in Heart of Darkness, must be admitted if one's inclination is to go to the limits of horror. It is the sense of what should not be- the sense of being ravaged by the impossible. Phenomenally speaking, the super-natural may be regarded as the metaphysical counterpart of insanity, a transcendental correlative of a mind that has been driven mad. Again, Ligotti equates madness with thought, qualifying both as supernatural while remaining less emphatic about the metaphysical dimensions of horror. The question becomes one of how exactly the hallucinatory realm of the ideal relates to the black churning matter of Lovecraft's chaos of elementary particles. In his tale “I Have a Special Plan for This World” Ligotti formulates thus: A: There is no grand scheme of things. B: If there were a grand scheme of things, the fact – the fact – that we are not equipped to perceive it, either by natural or supernatural means, is a nightmarish obscenity. C: The very notion of a grand scheme of things is a nightmarish obscenity. Here Ligotti is not discounting metaphysics but implying that if it does exist the fact that we are phenomenologically ill-equipped to perceive that it is nightmarish. For Ligotti, nightmare and horror occur within the circuit of consciousness whereas for Lovecraft the relation between reality and mind is less productive on the side of mind. It is easier to ascertain how the Kantian philosophy is a defense against the diseases of the head as Kant armors his critical enterprise from too much of the world and too much of the mind. The weird fiction of both Lovecraft and Ligotti demonstrates that there is too much of both feeding into one another in a way that corrodes the Kantian schema throughly, breaking it down into a dead but still ontologically potentiated nigredo. The haunting, terrifying fact of Ligotti's idealism is that the transcendental motion which brought thought to matter, while throughly material and naturalized, brings with it the horror that thought cannot be undone without ending the material that bears it either locally or completely. Thought comes from an elsewhere and an elsewhen being-in-thought. The unthinkable outside thought is as maddening as the unthought engine of thought itself within thought which doesn't exist except for the mind, the rotting décor of the brain. /5/ - Hyperstitional Transcendental Paranoia or Self -Expelled Thought Weird fiction has been given some direct treatment in philosophy in the mad black Deleuzianism of Nick Land. Nick Land along with others in the 1990s created the Cyber Culture Research Unit as well as the research group Hyperstition. The now defunct hyperstitional website, an outgrowth of the Cyber Culture Research Unit, defined hyperstition in the following fourfold: 1-Element of effective culture that makes itself real. 2-Fictional quantity functional as a time-traveling device. 3-Coincidence intensifier. 4-Call to the Old Ones. The distinctively Lovecraftian character of hyperstition is hard to miss as is its Deleuzo-Guattarian roots. In the opening pages of A Thousand Plateaus Deleuze and Guattari write, “We have been criticized for over-quoting literary authors. But when one writes, the only question is which other machine the literary machine can be plugged into”. The indisinction of literature and philosophy mirrors the mess of being and knowing as post-correlationist philosophy, where philosophy tries to make itself real where literature, especially the weird, aims itself at the brain-circuit of horror. The texts of both Lovecraft and Ligotti work through horror as epistemological plasticity meeting with proximity as well as the deep time of Lovecraft and the glacially slow time of paranoia in Ligotti. Against Deleuze, and following Brassier, we cannot allow the time of consciousness, the Bergsonian time of the duree, to override natural time, but instead acknowledge that it is an unfortunate fact of existence as a thinking being. Horror-time, the time of consciousness, with all its punctuated moments and drawn out terrors, cannot compare to the deep time of non-existence both in the unreachable past and the unknown future. The crystalline cogs of Kant's account of experience as the leading light for the possibility of metaphysics must be throughly obliterated. His gloss of experience in Prolegomena to any Future Metaphysics could not be more sterile: Experience consists of intuitions, which belong to the sensibility, and of judgments, which are entirely a work of the understanding. But the judgments which the understanding makes entirely out of sensuous intuitions are far from being judgments of experience. For in the one case the judgment connects only the perceptions as they are given in sensuous intuition [....] Experience consists in the synthetic connection of appearances in consciousness, so far as this connection is necessary. Here it is difficult to dismiss the queasiness that Kant's legalism induces upon sight for both Badiou and David-Menard. Kant's thought becomes, as Foucault says when reflecting on Sade's text in relation to nature, “the savage abolition of itself”. For Badiou, Kant's philosophy simply closes off too much of the outside, freezing the world of thought in an all too limited formalism. Critical philosophy is simply the systematized quarantine on future thinking, on thinking which would threaten the formalism which artificially grants thought its own coherency in the face of madness. Even the becoming-mad of Deleuze, while escaping the rumbling ground, makes grounds for itself, mad grounds but grounds which are thinkable in their affect. The field of effects allows for Deleuze's aesthetic and radical empiricism, in which effects and/or occasions make up the material of the world to be thought as a chaosmosis of simulacra. Given a critique of an empiricism of aesthetics, of the image, it may be difficult to justify an attack on Kantian formalism with the madness of literature, which does not aim to make itself real but which we may attempt to make real. That is, how do Lovecraft's and Ligotti's materials, as materials for philosophy to work on, differ from either the operative formalisms of Kant or the implicitly formalized images of Deleuzian empiricism? It is simply that such texts do not aim to make themselves real, and make claims to the real which are more alien to us than familiar, which is why their horror is immediately more trustworthy. This is the madness which Blanchot discusses in The Infinite Conversation through Cervantes and his knight – the madness of book-life, of the perverse unity of literature and life a discussion which culminates in the discussion of one of the weird's masters, that of Kafka. The text is the knowing of madness, since madness, in its moment of becoming-more-mad, cannot be frozen in place but by the solidifications of externalizing production. This is why Foucault ends his famous study with works of art. Furthermore extilligence, the ability to export the products of our maligned brains, is the companion of the attempts to export, or discover the possibility of intelligences outside of our heads, in order for philosophy to survive the solar catastrophe. To borrow again from Deleuze, writing is inseparable from becoming. The mistake is to believe that madness is reabsorbed by extilligence, by great works, or that it could be exorcised by the expelling of thought into the inorganic or differently organic. Going out of our heads does not guarantee we will no longer mean we cannot still go out of our minds. This is simply because of the outside, of matter, or force, or energy, or thing-in-itself, or Schopenhauerian Will. In Lovecraft’s “The Music of Erich Zahn” an “impoverished student of metaphysics” becomes intrigued by strange viol music coming from above his room. After meeting the musician the student discovers that each night he plays frantic music at a window in order to keep some horridness at bay, some “impenetrable darkness with chaos and pandemonium”. The aesthetic defenses provided by the well trained brain can bear the hex of matter for so long, the specter of unalterability within it which too many minds obliterate, collapsing everything before the thought of thought as thinkable or at least noetically mutable on our own terms. Transcendental paranoia is the concurrent nightmare and promise of Paul Humphrey's work, of being literally out of our minds. It is the gothic counterpart of thinking non-conceptually but also of thinking never belonging to any instance of purportedly solid being. As Bataille stated, “At the boundary of that which escapes cohesion, he who reflects within cohesion realizes there is no longer any room for him” Thought is immaterial only to the degree that it is inhuman, it is a power that tries, always with failure, to ascertain its own genesis. Philosophy, if it can truly return to the great outdoors, if it can leave behind the dead loop of the human skull, must recognize not only the non-priority of human thought, but that thought never belongs to the brain that thinks it, thought comes from somewhere else. To return to the train image from the beginning “a locomotive rolling on the surface of the earth is the image of continuous metamorphosis” this is the problem of thought, and of thinking thought, of being no longer able to isolate thought, with only a thought-formed structure. [1] One of the central tenets of Francois Laruelle's non-philosophy is that philosophy has traditionally operated on material already presupposed as thinkable instead of trying to think the real in itself. Philosophy, according to Laruelle, remains fixated on transcendental synthesis which shatters immanence into an empirical datum and an a prori factum which are then fused by a third thing such as the ego. For a critical account of Laruelle's non-philosophy see Ray Brassier's Nihil Unbound. (shrink)

Regarding the relation of Plato’s early and middle period dialogues, scholars have been divided to two opposing groups: unitarists and developmentalists. While developmentalists try to prove that there are some noticeable and even fundamental differences between Plato’s early and middle period dialogues, the unitarists assert that there is no essential difference in there. The main goal of this article is to suggest that some of Plato’s ontological as well as epistemological principles change, both radically and fundamentally, between the early and (...) middle period dialogues. Though this is a kind of strengthening the developmentalistic approach corresponding the relation of the early and middle period dialogues, based on the fact that what is to be proved here is a essential development in Plato’ ontology and his epistemology, by expanding the grounds of development to the ontological and epistemological principles, it hints to a more profound development. The fact that the bipolar and split knowledge and being of the early period dialogues give way to the tripartite and bound knowledge and benig of the middle period dialogues indicates the development of the notions of being and knowledge in Plato’s philosophy before the dialogues of the middle period. -/- Keywords Plato; early dialogues; middle dialogues; being; knowledge; development -/- Introduction The differences between two groups of the early and middle period dialogues have always been a matter of dispute. Whereas the developmentalists like Vlastos, Silverman (2002), Teloh (1981), Dancy (2004) and Rickless (2007) think that from the early to the middle dialogues Plato’s philosophy changes, at least in some essential points, the unitarists like Kahn, Cherniss and Shorey believe that there happens no development and the differences must be taken as natural, ignorable and even pedagogic. In his well-known article, Socrates contra Socrates in PLATO, Vlastos lists ten theses of difference between two groups of dialogues. The first group which includes Plato’s early dialogues he divides to 'elenctic' (Apology, Charmides, Crito, Euthyphro, Gorgias, Hippias Minor, Ion, Laches, Protagoras and Republic I) and 'transitional' (Euthydemus, Hippias Major, Lysis, Menexenus and Meno) dialogues. These transitional come after all the elenctic dialogues and before all the dialogues of the second group which compose Plato’s middle period dialogues, including (with Vlastos' chronological order) Cratylus, Phaedo, Symposium, Republic II-X, Phaedrus, Parmenides and Theaetetus (1991, 46-49). Vlastos asserts strictly that his list of differences are 'so diverse in content and method that they contrast as sharply with one another as with any third philosophy you care to mention, beginning with Aristotole’s' (ibid, 46). Vlastos’ list of differences between two Socrateses is considered a view breaking sharply between the early and the middle dialogues. Besides all ten differences between the two Socrateses in Vlastos’ list that can be supportive for our doctrine here, we intend to focus on some ontological as well as epistemological distinctions that have not completely been discussed hitherto. Contrary to the developmentalist theory of Vlastos, unitarian theory of Charles Kahn wishes to eliminate any substantial difference between the early and the middle dialogues. He distinguishes seven 'pre-middle' or 'threshold' dialogues including Laches, Charmides, Euthyphro, Protagoras, Meno, Lysis and Euthydemus from the other Socratic dialogues which he calls 'earliest group' (1996, 41). The threshold dialogues, Kahn thinks, 'embarke upon a sustained project' that is to reach to its climax in the middle period dialogues, namely Phaedo, Symposium and Republic. Believing in that there is no 'fundamental shift'between the early and middle dialogues (ibid, 40), Kahn thinks the Socratic dialogues are just the 'first stage' with a 'deliberate silence' towards the theories of later periods (ibid, 339). One of the reasons of the surprising fact that Plato gives no hint of the metaphysics and epistemology of the Forms in the early dialogues, he thinks, is the pedagogical advantages of aporia. He thinks that Plato 'obscurely', and mostly because of education, hinted to some doctrines and conceptions in his early dialogues and with the aim of clarifying them only in the later ones (ibid, 66). The seven threshold dialogues, Kahn asserts, 'had been designed from the first' to prepare the pupils and readers for the views expounded in the middle period dialogues (ibid, 59-60). To show that the differences of the two Socrateses of the early and middle period dialogue are in their onto-epistemological grounds and thence cannot be explained by a unitaristic view, we try to draw the ontological and epistemological principles of the early dialogues in the first part below in order to show, in the second part, that those principles have been developed in the middle period dialogues. -/- A. The Onto-Epistemologic Principles of the Early Dialogues Socratic dialogues are paradoxical about knowledge because while being knowledge-oriented always searching for knowledge, they deny it and even never discuss it directly. Three elements of Socrates’ way of searching Knowledge throughout the early dialogues, i.e. Socratic 'what is X?' question, his disavowal of knowledge and his elenctic method combined together produce something like a circle which works, more or less, in the same way in these dialogues. Though this circle is an embaressing inquiry always resulting in ignorance instead of knowledge, its motivation is surprisingly Socrates’ passionate enthusiasm for knowledge, an intensive love of wisdom. The starting point of this circle is Socrates’ confession of having no knowledge which might be explicitly asserted or presupposed, maybe because it was one of the famous characteristics of Socrates; a confession always paradoxically accompanied with his intense longing for knowledge (e.g., Gorgias 505e4-5). Every time Socrates encounters with someone who thinks he knows something (οἴεταί τι εἰδέναι) (Apology 21d5) and tries to examine him. This examination seems to be the simplest one asking just what it is that he knows. Socrates’ elenchus, therefore, is always connected with 'what is X?' (τίς ποτέ ἐστιν) question, a question that most of the early dialogues of Plato are concerned with; 'what is courage?' in the Laches, 'what is piety?' in Euthydemus, 'what is temperance?' in Charmides and 'what is beauty?' in Hippias Major. This question we call here 'Socratic question' and probably is the very question the historical Socrates used to employ, is tightly interrelated with both his disavowal and his elenchus. He disclaims knowledge because he cannot find the answer to the question himself and he rejects others’ since they cannot offer the correct answer too. Every interlocutor can claim he knows X, if and only if he can answer the Socratic question. Otherwise, he is more of an ignorant than of a knower of τί ποτέ ἐστι X. Knowing the answer to this question is, thus, knowledge’s criterion for Socrates. Having found out that he cannot answer what it is which he would claim to know, the interlocutor comes to the point Socrates was there at the beginning. The least advantage of this circle is that he becomes as wise as Socrates does about the subject, becoming aware that he does not know it. At the end of the circle they are both still at the beginning, not knowing what X is. So let us first take a glance at these three elements. Socratic disavowal of knowledge is strictly asserted in some passages. At Apology 21b4-5, Socrates says: -/- I do not know of myself being wise at all (οὔτε μέγα οὔτε σμικρὸν σύνοιδα ἐμαυτῷ σοφὸς ὤν) -/- Moreover, at 21d4-6: -/- None of us knows anything worthwhile (καλὸν κἀγαθὸν εἰδέναι) …. I do not know (οἶδα) neither do I think I know. -/- In Charmides Socrates speaks about a fear about his probable mistake of thinking that he knows (εἰδέναι) something when he does not (166d1-2). The somehow generalization of this disavowal can be seen in Gorgias. After calling his disavowal 'an account that is always the same' (509a4-5), Socrates continues (a5-7): -/- I say that I do not know (οἶδα) how these things are, but no one I have ever met, like now, who can say anything else without being absurd. -/- At the end of Hippias Major (304d7-8), Socrates affirms his disavowal of knowledge of 'what is X?' this time about the fine: -/- I do not know (οἶδα) what that is itself (αὐτὸ τοῦτο ὅτι ποτέ ἐστιν). Some other passages, however, made a number of scholars dubious about Socrates’ disavowal. Vlastos mentions Apology 29b6-7 as an evidence : 'that to do wrong and to disobey one’s master, both god and men, I know (οἶδα) to be evil and shameful'. He thinks that if we give this single text 'its full weight' it can suffice to show that Socrates does claim knowledge of a moral truth (1985, 7). Vlastos’ claim is not admittable since it would be too strange, I think, for a man like Socrates to violate his disavowal claim just after emphasizing it. We can see his claim just before the already mentioned passage: -/- And surely it is the most blameworthy ignorance to believe that one knows what one does not know. It is perhaps on this point and in this respect, gentlemen, that I differ from the majority of men and if I were to claim that I am wiser than anyone in anything it world be in this, that, as I have no adequate knowledge (οὐκ εἰδὼς ἱκανῶς) of things in the underworld, so I do not think I have (οὐκ εἰδέναι) (Apology 29b1-6) Vlastos tries to solve what he calls the 'paradox' of Socrates’ disavowal of knowledge distinguishing the 'certain' knowledge from 'elenctic' knowledge (1985, 11) and thinking that when Socrates avows knowledge, we must perceive it as an elenctic knowledge, a knowledge its content 'must be propositions he thinks elenctically justifiable' (ibid, 18). Irwin’s solution is the distinction of knowledge and belief. He approves that Socrates does not 'explicitly' make such a distinction, but still thinks that Socrates’ 'test for knowledge would make it reasonable for him to recognize true belief without knowledge, and his own claims are easily understood if they are claims to true belief alone' (1977, 40). While I agree with Vlastos up to a point, I strongly disagree with Irwin about the early dialogues. As I will try to show below, we are not permitted to consider any kind of distinction within knowledge in Socratic dialogues because only one category of knowledge is alluded to there and the distinction of knowledge and belief thoroughly belongs to the second Sorcates. Although no kind of distinction can be admittable here, I think Vlastos’ distinction can be accepted only if we regard it as a distinction between knowledge, which is unique and without any, even incomparable, rival, and a semi-idiomatic and ordinary one that is a necessary requirement for any argument, and thus, unavoidable even for someone who does not claim any kind of knowledge. An apparent evidence of this is Gorgias 505e6-506a4: -/- I go through the discussion as I think it is (ὡς ἄν μοι δοκῇ ἔχειν), if any of you do not agree with admissions I am making to myself, you must object and refute me. For I do not say what I say as I know (οὐδὲ γάρ τοι ἔγωγε εἰδὼς λέγω ἃ λέγω) but as searching jointly with you (ζητῶ κοινῇ μεθ᾽ ὑμῶν). -/- The minimal degree of knowledge everyone must have to take part in an argument, conduct it and use the phrase "I know" when it is necessary is what Socrates cannot deny. We can call it elenctic knowledge only if we agree that it is not the kind of knowledge that Socrates has always been searching, the one that can be accepted as the answer of Socratic 'what is X?' question. His disavowal of knowledge is applied only to the knowledge which can truly be the answer of Socratic question and pass the elenctic exam; a knowledge that, I believe, is never claimed by first Socrates. Socrates conducts his method of examining his interlocutors’ knowledge, our second element here, by almost the same method repeated in Socratic dialogues. That whether we are allowed to regard all the examinations of Socrates in the early dialogues as based on the same or not has been a matter of dispute. Vlastos himself (1994, 31) distinguished Euthydemas, Lysis, Menexenns and Hippias Major from the other Socratic dialogues because he thinks Socrates has lost his faith to elenchus in there. Irwin (1977, 38) distinguishes Apology and Crito where Socrates’ own convictions is present. Contrary to some scholars like Benson (2002, 107) who take elenchus in all the Socratic dialogues as a unique method, Michelle Carpenter and Ronald M. Polansky (2002, 89-100) argue pro the variety of methods of elenchus. Thomas C. Brickhouse and Nicholas D. Smith (2002, 145-160) even reject such a thing as Socratic elenchus which can gather all of the Socrates’ various arguments under such a heading. There can be no solution for the problem of elenchus, they think, is due to 'the simple reason that there is no such thing as 'the Socratic elenchos"'(p.147). Though we consider elenchus a somehow determined process and a part of Socratic circle in the early dialogues, all we assume is that whatever differences it might have in different dialogues, it has the same onto-epistemological principles and, thus, we are not going to take it necessarily as a unique method. This method sets out to prove that the interlocutors are as ignorant as Socrates himself is. That whether elenchus is constructive, capable of establishing doctrines as Vlastos (1994) or Brickhouse and Smith (1994, 20-21) believe or not is another issue to which this paper is not to claim anything. What is crucial for our discussion here is that elenchus does not reach to the very knowledge Socrates is looking for. This is strictly against Irwin who thinks that not only elenchus leads to positive results, 'it should even yield knowledge to match Socrates’ conditions'(1977, 68, cf. 48). He does not explain where and how they really yield to that kind of knowledge. He explains his elenctic method in his apology in the court (Apology 21-22), that how he used to examine wise men, politicians, poets and all those who had the highest reputation for their knowledge and every time found that they have no knowledge. If we accept, as I strongly do, that Socrates’ disavowal of his knowledge is not irony, it might seem more reasonable to agree that the process that has that disavowal as its first step cannot be irony as well. The key of the circle which can explain why Socrates disclaims knowledge and how he can reject others’ claim of having any kind of knowledge lies in the third element, Socratic question. In Hippias Major (287c1-2), Socrates asks: 'Is it not by Justice that just people are Just? (ἆρ᾽ οὐ δικαιοσύνῃ δίκαιοί εἰσιν οἱ δίκαιοι). He insists at 294b1 that they were searching for that by which (ᾧ) all beautiful things are beautiful (cf. b4-5, 8). At Euthyphro 6d10-11 it is said that the Socratic question is waiting for 'the form itself (αὐτὸ τὸ εἶδος) by which (ᾧ) all the pious actions are pious; and at 6d11-e1: -/- Through one form (που μιᾷ ἰδέᾳ) impious actions are impious and pious actions pious. -/- Since the X itself is that by which X is X, knowing 'X itself' is the only way of knowing X. It is probably because of this that Socrates makes the distinction between the ousia as a right answer to the question and effect as a wrong one: -/- I am afraid, Euthyphro, that when you were asked what piety is (τὸ ὅσιον ὅτι ποτ᾽ ἐστίν) you did not wish to make clear its nature itself (οὐσίαν … αὐτοῦ) to me, but you said some effect (πάθος) about it. (Euthp. 11a6-9) -/- 1. Knowledge of what X is Now it is time to look for the onto-epistemological principles of Socratic circle and its three elements. It cannot reasonably be expected from the first Socrates to present us explicitly and clearly formulated principles of his onto-epistemology when such explications cannot be found even in the second Socrates who has some obviously positive theoris. Since there must be some principles underlying this first systematic inqury of knowledge, we must seek to them and be satisfied with elicitation of the first Socratas’ principle. What will be drawn out as his principles cannot and must not, thus, be taken as very fix and dogmatic principles. Some very slightest principles and grounds suffice for our purposes here. The first principle that is the prima facie significance of the Socratic question and his implementation of all those elenctic arguments I call the principle of 'Knowledge of What X is' (KWX): -/- KWX To know X, it is required to know what X is. -/- Aristotle (Metaphysics 1078b23-25, 27-29, 987b4-8) takes Plato’s τί ἐστι question as seeking the definition of a thing that is the same as historical Socrates’ search but applying to a different field. That Plato’s 'what is X?' question was a search for definition became the prevailed understanding of this question up to now. I am going neither to discuss the answer of Socratic question nor to challenge taking it as definition. What I am to insist is that knowledge is attached firmly to the answer of the question: Knowledge of X is not anything but the knowledge of what X is. It entails, certainly, the priority of this knowledge to any other kind of knowledge about X but it also has something more fundamental about the relation of knowledge and Socratic question. Socrates’ exclusive focus on the answer of his question can authorize the consideration of such an essential role for KWX in his epistemolgoy. The total rejection of his interlocutors’ knowledge when they are unable to answer the question can be regarded as a strong evidence for it. Socrates’ elenctic method and his rejection of others’ knowledge in the early dialogues, which all end aporetically with no one accepted as knower and nothing as knowledge, prevent us from finding any positive evidence for this. We have to be content, therefore, of negative evidences which, I think, can be found wherever Socrates rejects his interlocutors’ knowledge when they are not able to give an acceptable answer to his 'what is X?' question. 2. Bipolar Epistemology Socrates’ rejection of his interlocutors’ knowledge has another epistemological principle as its basis. Let me call this principle Bipolar Epistemology' (BE): BE There is no third way besides knowledge and Ignorance. -/- BE says that about every object of knowledge there are only two subjective statuses: knowledge and Ignorance. Socrates’ disavowal, however, says nothing but that he is ignorant of knowledge of X because he does not know what X is. This means that BE is presupposed here. Socrates’ elenchus and his rejection of interlocutors’ having any kind of knowledge are the necessary results of the fact that he does not let any third way besides knowledge and ignorance. The first Socrates never let anyone partly know X or have a true opinion about it, as he would not let anyone know anything about X when he did not know what X is. -/- 3. Bipolar Ontology The principle of BE in first Socrates’ epistemology is parallel to another principle in his ontology. Plato’s bipolar distinction between being and not being is as strict and perfect as his distinction between knowledge and ignorance. This principle I shall call the principle of 'Bipolar Ontology' (BO): BO Being is and not being is not. BO is apparently the same with the well-known Parmenidean Principle of being and not being (cf. Diels-Kranz (DK) Fr. 2.2-5). Euthydemus’ statement against the possibility of false knowledge can be good evidence for this principle: -/- The things which are not surely do not exist (τὰ δὲ μὴ ὄντα … ἄλλο τι ἢ οὐκ ἔστιν). (Euthydemus 284b3-4) -/- He continues (b4-5): -/- There is nowhere for not being to be there (οὖν οὐδαμοῦ τά γε μὴ ὄντα ὄντα ἐστίν). -/- That BE does not let true opinion as a third option besides knowledge and ignorance seems to be related to BO’s rejecting a third option besides being and not being, which is itself the basis of the impossibility of false belief. Socrates’ elaborate discussion of the problem of false belief in Theatetus that leads to a more decisive discussion and finally to some solutions in Sophist can make our consideration of BO for the first group of dialogues authentive. -/- 4. &5. Split Knowledge and Split Being The fourth principle I shall call the principle of 'Split Knowledge' (SK): -/- SK Knowledge of X is separated from any other knowledge (of anything else) as if the whole knowledge is split to various parts. -/- This Principle is hinted and criticized as Socrates’ way of treating with knowledge in Hippias Major: -/- But Socrates, you do not contemplate the entireties of things, nor do people you have used to talk with (τὰ μὲν ὅλα τῶν πραγμάτων οὐ σκοπεῖς, οὐδ᾽ ἐκεῖνοι οἷς σὺ εἴωθας διαλέγεσθαι). (301b2-4) -/- Contrary to Rankin who regards the passage as 'antilogical, almost eristic in tone rather than presenting a serious philosophy of being' (1983, 54), I think it can be taken as serious. Hippias criticizes Sorcates that he does not contemplate (σκοπεῖς) the entireties of things (ὅλα τῶν πραγμάτων), a critique which Socrates is not its only subject but all those whom Socrates accustomed to talk with (ἐκεῖνοι οἷς σὺ εἴωθας διαλέγεσθαι). This last phrase, I think, extends this critic beyond this dialogue to other Socratic dialogues. Hippias’ use of the perfect tense of the verb ἔθω (to be accustomed) is a good evidence of this extension. We can get, thus, these ἐκεῖνοι as Socrates’ interlocutors in his other dialogues that hints that this criticism has the epistemological groundings of the previous dialogues as its subject. What ἐκεῖνοι οἷς σὺ εἴωθας διαλέγεσθαι points to is that Hippias does not have in mind Socrates’ way of treating things only in this dialogue, but he is also criticizing Socrates’ way throughout his dialogues. At 301b4-5, Socrates and his interlocutors’ way of beholding things is described as such: -/- You people knock (κρούετε) at the fine and each of the beings (ἕκαστον τῶν ὄντων) by taking each being cut up in pieces (κατατέμνοντες) in words (ἐν τοῖς λόγοις). This leads us to our next principle that is parallel to, and the ontological side of, SK, the principle of 'Split Being'(SB): -/- SB Everything (being) is separated from any other thing as if the whole being is split to many beings. -/- Socrates and his interlocutors and thus, as we saw, the Socratic dialogues are accused to regard everything as it is separated from all other things. This separation is en tois logois that, I think, can reasonably be taken as saying that Socratic dialogues (it refers of course to the dialogues before Hippias Major) cut up all things which have the same name/definition from all other things and try to understand them separately, without considering other things that are not in their logos. They, for example in Hippias Major, are cutting up to kalon and try to understand what it and all others inside this logos are by separating it from all other things. This is directed straightly against Socratic question and the way Socratic dialogues follow to find its answer, every time separating one logos. As Meyer (1995, 85) points out, every question 'presupposes that the X in question in a logos is something' and 'every answer to every question aims at unity' (84). The critique of Hippias Major is, therefore, at the same time a critique of SK and SB. It is also a critique of KWX because it is only based on KWX that Socratic dialogues could search for the answer of 'what is X' question supposing that knowing what X is is enough for the knowledge of X. SK and KWX are absolutely interdependent. What Socrates and all his previous interlocutors have neglected in Socratic dialogues, Hippias says, was 'continuous bodies of being' (διανεκῆ σώματα τῆς οὐσίας) (301b6). Either this theory actually belongs to the historical Hippias as it is being said or not, it is strictly criticizing SB. We have the same phrase with changing sūma to logos some lines later at 301e3-4: διανεκεῖ λόγῳ τῆς οὐσίας. Although this theory that can be observed as both an ontological and an epistemological theory is rejected by Socrates (301cff.), it is still against first Socrates’ onto-epistemological principles and might let us look at what is rejected as Socratic prineple. -/- 6. Knowledge is of Being The sixth principle that I think is presupposed by the first Socrates, is the 'Knowledge of Being' Principle (KB): -/- KB Knowledge is of Being. -/- This principle is obviously the source of the problem of false knowledge, a very important problem throughout Plato’s philosophy. We face this problem maybe for the first time in Euthydemus. In less than 20 Stephanus’ pages, 276-295, we are encountered with different interwoven problems about knowledge , all grounded in the problem of false opinion. Having challenged the obvious possibility of telling lies at 283e, at 284 Euthydemus discusses it saying that the man who speaks is speaking about 'one of those things that are (ἓν μὴν κἀκεῖνό γ᾽ ἐστὶν τῶν ὄντων)' (284a3) and thus speaks what is (λέγων τὸ ὄν) (a5). He must necessarily be saying truth when he is speaking what is because he who speaks what is (τὸ ὄν) and the things that are (τὰ ὄντα) speaks truth (τἀληθῆ λέγει) (a5-6). This is based on Parmenidean principle of the impossibility of being of not being which Euthydemus restates (284b3-4) and we mentioned discussing BO principle above. The things that are not are nowhere (οὐδαμοῦ) and there is no possibility for anyone to do (πράξειεν) anything with them because they must be made as being before anything else can be done, which is impossible (b5-7). The words, then, are of things that exist (εἰσὶν ἑκάστῳ τῶν ὄντων λόγοι) (285e9) and as they are (ὡς ἔστιν) (e10). The result is that no one can speak of things as they are not. It is this impossibility of false speach that is extended to thinking (δοξάζειν) at 286d1 and leads to the impossibility of false opinion (ψευδής … δόξα) (286d4). The general conclusion is asserted at 287a extending this impossibility to actions and making any kind of mistake. Not only knowledge is of being but speech, thought and action are of being simply because of the fact that nothing can be of not being. -/- B. First Socrates’ Principles in the Middle Period Dialogues Out of what were presupposed or criticized mostly in five dialogues, Euthyphro, Euthydemus, Hippias Major, Laches and Charmides, we tried to draw the first Socrates’ principles. Our inquiry here is directed to find out the fate of these principles in the three dialogues of the middle period, Meno, Phaedo and Republic. To do this, first we ought to check the situation of Socratic circle in these dialogues. The Socratic circle that was predominant in the early dialogues, does not look like a circle here anymore though they certainly have some features in common. Meno, Phaedo and Republic II-X are not committed to the principles of the circle and the whole circle in disrupted in them. The difference of the two Socrateses towards acquiring knowledge is obvious. The Socrates of Meno, Phaedo and Republic is evidently more self-confident that he can get to some truths during his arguments as he does. They are in their first appearance, as almost all other dialogues, committed to Socrates’ disavowal. All of them try to keep the shape of the Socratikoi Logoi genre, which is committed to the historical Socrates’ way of discussion; a dramatic personage who is to challenge his interlocutors, ask them and refuse the answers. Nevertheless, the fact is that what we have in common between two groups of dialogues is mostly a dramatic structure. Whereas the first group’s arguments are based on Socrates’ disavowal and lead to no positive results, the second group is decisively going to achieve some positive results. The aim of the first Socrates was to show others that they are ignorant of what they thought they knew. The new Socrates of Meno, on the opposite, makes so much efforts to show that the slave boy has within himself true opinions (ἀληθεῖς δόξαι) about the things that he does not know (οἶδε) (85c6-7). Despite his lack of knowledge, he has true opinions nevertheless. The way from these true opinions to knowledge, as Socrates states, is not so long. These true opinions are now like a dream but 'can become knowledge of the same things not less accurate than anyone’s' (οὐδενὸς ἧττον ἀκριβῶς ἐπιστήσεται περὶ τούτων) (c11-d1), if they be repeated by asking the same questions. The most outstanding text regarding Socrates’ disavowal is Meno 98b where he explicitly claims knowledge: -/- And indeed I also speak as (ὡς) one who does not know (εἰδὼς) but is guessing (εἰκάζων). However, [about the fact] that true opinion and knowledge are different, I do not altogether expect (δοκῶ) myself to be guessing (εἰκάζειν), but if I say about anything that I know (εἰδέναι) -which about few things I say- this is one of the things that I know (οἶδα). (98b1-5) This passage is very significant about Plato’s disavowal of knowledge. There can hardly be found, I think, anywhere else in Plato’s corpus where Socrates speaks about his knowledge of something as such. He says first that he speaks as someone who does not know. This ὡς οὐκ εἰδὼς λέγω comparing with what he used to say in the first group, οὐκ οἶδα, has this added ὡς. Socrates does not claim strongly anymore that he does not know anything but speaks only as someone who does not know. He needs this ὡς not only because he is going to accept that he does know some, though few, things immediately after this sentence, but also because he needs his previous disavowal to be loosened from Meno on. He does not merely say here that he knows something. It is then different from the examples mentioned before which could be taken as idiomatic or at least not emphatic. Socrates’ remarkable emphasis on distinguishing εἰδέναι from εἰκάζειν departs it from all other passages where he says only he knows something. Moreover, he claims definitely that he has knowledge about few (ὀλίγα) things. From the early to the middle dialogues, Socrates’ attitude to knowledge has totally renewed its face. He brings forth a new concept, true opinion, and he does not speak of knowledge as he used to before; the rough, perfect and unachievable knowledge of the first group has turned to something more smooth, realistic and achievable. Comparing with the early dialogues that did not set out from the first to reach positive results, the middle ones are extraordinarily and surprisingly positive and hence destroy the basis of the Socratic circle. The questions and answers are purposely directed to some specific new theories; most of them are not directly related to the topics or the main questions of the dialogues. They are suggested when Socrates draws the attention of the interlocutor away from the main question because of the necessity of another discussion. Even if the main question remains unanswered, we have still many positive theories, prominently of metaphysical type. These theories are so abundant and dominant in these dialogues, especially Phaedo and Republic, that one might think that they may appear to be arbitrarily sandwiched in there. This helps dialogues to keep their original Socratic structure while they are suggesting new theories. Hence, the Socratic question of 'what is X?', though is still used to launch the discussion, is loosened and is forgotten for most part of the dialogues. Meno that has first a differently formulated question, 'can virtue be taught?', leads finally to the Socratic question of 'What is virtue?'. Phaedo is dedicated to the demonstration of the immortality of soul and the life after death without having a central Socratic question. The case of Republic is more complicated. The first book, on the one hand, has all the criteria of a Socratic circle: its 'what is justice?' question, Socrates’ strong disavowal (e.g. 337d-e), his rejection of all answers and coming back to the first point without finding out any answer. This Book, considered alone, is a perfect Socratic dialogue, as many scholars regard it as early and separated from other books. The books II-X are, on the other hand, far from implementing a Socratic circle. They have still the 'what is justice?' question as their incentive leading question, but they are, in most of the positive doctrines and methods that encompass the main parts, ignoring the question. Even these books that, I believe, are the farthest discussions from the Socratic circle are so cautious not to break the Socratic structure of the dialogue as long as it is possible. What is changed is not the structure of the dialogue but the ontological and epistemological grounds based on which new theories are suggested. -/- 1. Knowledge of the Good We can clearly see in the second group of dialogues that the KWX principle loses the place it had before in our first group. It is not, of course, rejected, but still we cannot say that it has the same situation. KWX that was based on Socratic question, as we discussed before, was the leading principle of the first Socrates’ epistemology and of the highest position. Other epistemological principles, SK directly and BE indirectly, were relying on Socratic question and therefore on KWX. Such a position does not belong to KWX from Meno on. What makes it different in the second Socrates is another principle that is needed it not only as its complementary principle but also as what is more fundamental. Plato, then, does not reject KWX in this period, but, it seems, he transcends to another more basic principle; a principle we shall call the principle of 'Knowledge of the Good' (KG): -/- KG Knowledge of X requires knowledge of the Good. -/- Whereas all the dialogues of our first group are free from any discuscon about KG, it bears a very important role in the second group so as becomes the superior principle of knowledge in Republic. Trying to solve the problem of teachability of virtue, Socrates says that it can be teachable only if it is a kind of knowledge because nothing can be taught to human beings but knowledge (ἐπιστήμην) (Meno 87c2). The dilemma will be, then, whether virtue is knowledge or not (c11-12) and since virtue is good, we can change the question to: whether is there anything good separate from knowledge (εἰ μέν τί ἐστιν ἀγαθὸν καὶ ἄλλο χωριζόμενον ἐπιστήμης) (d4-5). Therefore, the conclusion will be that if there is nothing good which knowledge does not encompass, virtue can be nothing but knowledge (d6-8). What let us discuss KG as an epistemological principle for the second Secrates is the relation he tries to establish between knowledge and the Good which, though is alongside with the mentioned thesis and the idea of virtue as knowledge, goes much deeper inside epistemology asking to regard the Good as the basis of knowledge. The effort of Phaedo cannot succeed in establishing the Good as the criterion of explanation and knowledge since, I think, it needs a far more complicated ontology of Republic where Socrates can finally announce KG. What is said in Republic is totally compatible with Phaedo 99d–e and the metaphor of watching an eclipse of the sun. In spite of the fact that we do not have adequate knowledge of the Idea of the Good, it is necessary for every kind of knowledge: 'If we do not know it, even if we know all other things, it is of no benefit to us without it' (505a6-7). The problem of our not having sufficient knowledge of the Idea of Good is tried to be solved by the same method of Phaedo 99d-e, that is to say, by looking at what is like instead of looking at thing itself (506d8-e4). It is this solution that leads to the comparison of the Good with sun in the allegory of Sun (508b12-13). What the Good is in the intelligible realm corresponds to what the sun is in the visible realm; as sun is not sight, but is its cause and is seen by it (b9-10), the Good is so regarding knowledge. It has, then, the same role for knowledge that the sun has for sight. Socrates draws our attention to the function of sun in our seeing. The eyes can see everything only in the light of the day being unable to see the same things in the gloom of night (508c4-6). Without the sun, our eyes are dimmed and blind as if they do not have clear vision any longer (c6-7). That the Good must have the same role about knowledge based on the analogy means that it must be considered as a required condition of any kind of knowledge: -/- The soul, then, thinks (νόει) in the same way: whenever it focuses on what is shined upon by truth and being, understands (ἐνόησέν), knows (ἔγνω) and apparently possesses understanding (νοῦν ἔχειν). (508d4-6) -/- Socrates does not use agathon in this paragraph and substitutes it with both aletheia and to on. He links them with the Idea of the Good when he is to assert the conclusion of the analogy: -/- That which gives truth to the objects of knowledge and the power of knowing to the knower, you must say, is the Idea of the Good: being the cause of knowledge and truth (αἰτίαν δ᾽ ἐπιστήμης οὖσαν καὶ ἀληθείας) so far as it is known (ὡς γιγνωσκομένης μὲν διανοοῦ). (508e1-4) Knowledge and truth are called goodlike (ἀγαθοειδῆ) since they are not the same as the Good but more honoured (508e6-509a5). KG, which had been implicitly contemplated and searched in Phaedo, is now explicitly being asserted in Republic. As what was quoted clearly proves, this principle is the very one which we can observe as the most fundamental principle of the second Socrates in Republic, corresponding to the role KWX had in the first Socrates. The Form of the Good in Republic, of which Santas speaks as 'the centerpiece of the canonical Platonism of the middle dialogues, the centerpiece of Plato’s metaphysics, epistemology, ethics and …' (1983, 256) much more can be said. Plato’s Cave allegory in Book VIII dedicates a similar role to the Idea of the Good. The Idea of the Good is there as the last thing to be seen in the knowable realm, something so important that its seeing equals to understanding the fact that it is the cause of all that is correct and beautiful (517b). Producing both light and its source in visible realm, it controls and provides truth and understanding in the intelligible realm (517c). -/- 2. Tripartite Epistemology BE is thoroughy rejected in the second Socrates and substituted by its opposite, the principle of 'Tripartite Epistemolgy' (TE): -/- TE Opinion is an epistemological status between knowledge and ignorance. BE of the first Socrates was denying any third way besides knowledge and ignorance which was the foundation of Socratic circle without which Socrates could not reject his interlocutors’ possessing any kind of knowledge. We cannot say, however, that the first Socrates had a third epistemological status in mind but rejected it. Such a status was unacceptable for him so that one can say that he would reject any kind of such status if suggested. There were only two possibilities about knowledge: either one knows something or he does not know it. TE, thus, was not the first Socrates’ discovery and, I think it is not the second Socrates’discovery. All we can see in our second group of dialouges is that he uses this principle as an already demonstrated one. Having examined the slave boy in Meno for the prupose of showing the working of recollection, it truns out that he has some opinions in him while he still does not know. Without trying to prove it, Socrates takes this as the distinction between knowledge and opinion: -/- So, he who does not know (οὐκ εἰδότι) about what he does not know (περὶ ὧν ἂν μὴ εἰδῇ) has within himself true opinions (ἀληθεῖς δόξαι) about the same things he did not know (περὶ τούτων ὧν οὐκ οἶδε) (85c6-7). -/- The same distinction is set between ὀρθὴν δόξαν and ἐπιστήμην at 97b5-6 ff. (also cf. 97b1-2: ὀρθῶς μὲν δοξάζων … ἐπιστάμενος). He connects then their difference to the myth of Daedalus, the statue that would run away and escape. So are true opinions, not willing to remain long in mind and thus not worthy until one ties them down by αἰτίας λογισμῷ (98a3-4). Socrates says that this tying down is anamnesis. We face, in Phaedo, the same relation is settled between knowledge as the process of being tied down and getting the capability to give an account, on the one hand, and anamnesis, on the other hand. When a man knows, he must be able to give an account of what he knows (Phaedo 76b5-6) and since not all people are able to give such an account, those who recollect, recollect what once they learned (76c4). Although the distinction between knowledge and opinion is not explicitly used in Phaedo, referring to the parallel link between knowledge plus account and anamnesis in Phaedo and Meno, one can say that those who cannot recollect are not able to give account and, thus, are in a state of opinion. What is said at Phaedo 84a, though not yet a definite distinction between knowledge and opinion, makes a distinction between their objects so as we can agree that it is presupposed. The soul of the philosopher, Socrates says, follows reason, stays with it forever and contemplates the divine, which is not the object of opinoin (ἀδόξαστον) (84a8, cf. Meno 98b2-5). The distinction of knowledge and belief in Republic has a significant difference with what we discussed in Meno and Phaedo since the distinction of Meno was based on anamnesis and thus more an epistemological distinction. Even in Phaedo that we do not have any elaborate discussion about the distinction, the only hint to the matter at 76 is bound to the theory of anamnesis. In addition to the relation of the distinction with this theory, there is another evidence that does not permit us to consider the distinction as an ontological distinction. Let’s see Meno 85c6-7: -/- So, he who does not know about what he does not know has within himself true opinions about the same things he did not know (τῷ οὐκ εἰδότι ἄρα περὶ ὧν ἂν μὴ εἰδῇ ἔνεισιν ἀληθεῖς δόξαι περὶ τούτων ὧν οὐκ οἶδε). (85c6-7) -/- This last sentence persists that the objects of knowledge and true opinion are the same. What Socrates is to say here is that whereas he does not know X he has true opinion about the same X. I think Socrates’ sentence that the slave boy οὐκ εἰδότι ἄρα περὶ ὧν ἂν μὴ εἰδῇ and his restatement of it by saying περὶ τούτων ὧν οὐκ οἶδε is because he wants to emphasize that the slave boy who does not know, has true opinion about the same thing. Socrates could say this just with using τούτων and there would be no necessity to bring περὶ ὧν ἂν μὴ εἰδῇ for οὐκ εἰδότι if he did not want to emphasize. -/- 3. Tripartite Ontology The distinction between knowledge and true opinion in Republic, on other side, has nothing to do with recollection, but is based on an ontological principle, 'Tripartite Ontology' (TO): -/- TO There are things that both are and are not. -/- This principle I confine, among our three dialogues of the second group, to Republic not extended to Meno and Phaedo, is obviously the opposite of BO. Speaking about the lovers of sights and sounds in the fifth book, Socrates distinguishes them from philosophers because their thought is unable to understand the nature of beautiful itself besides beautiful things (476a6-8) and hence they can only have opinions. The philosopher who, on the contrary, believes in beautiful itself and can distinguish it from beautiful things (476c9-d3), has knowledge because he knows, contrasting others who have opinion because they only opine (d5-6). Since those whose knowledge were degraded as opinion will complain about Socrates’ such calling their thought, he provides them the following argument (476e7-477b1): -/- - Does the person who knows, knows (γιγνώσκει) something (τὶ) or nothing (οὐδέν)? - He knows something (τί). - Something that is (ὂν) or is not (οὐκ ὄν)? - Something that is (ὂν) for how could something that is not be known (πῶς γὰρ ἂν μὴ ὄν γέ τι γνωσθείη)? - Then we have an adequate grasp of this: No matter how many ways we examine it, what completely is (παντελῶς ὂν) is completely knowable (παντελῶς γνωστόν) and what is in no way (μὴ ὂν δὲ μηδαμῇ) is in every way unknowable (πάντῃ ἄγνωστον). - A most adequate one. - Good. Now, if anything is such as to be and also not to be (ὡς εἶναί τε καὶ μὴ εἶναι), won’t it be intermediate (μεταξὺ) between what purely is (εἰλικρινῶς ὄντος) and what in no way is (μηδαμῇ ὄντος)? - Yes, it’s intermediate. - Then as knowledge (γνῶσις) is set over what is (τῷ ὄντι), while ignorance (ἀγνωσία) is of necessity set over what is not (μὴ ὄντι) mustn’t we find an intermediate between ignorance (ἀγνοίας) and knowledge (ἐπιστήμης) to be set over the intermediate, if there is such a thing? -/- From the third status of being we must reach to the third status of knowledge. The simple reading of this text can be an existential reading, taking the "is" of the mentioned sentences as existence. The problem is that when it is said that there is something that both is and is not reading "is" existentially, it sounds too bizarre to be acceptable. It cannot easily be understandable to have something as both existent and non-existent at the same time. This problem arose so many debates and led many scholars to reject the existential reading of "is" and suggest some other readings like predicative or veridical readings. I think though Plato’s complicated ontology of Republic cannot be correctly understood by a simple existential reading, this "is" cannot be free from existential sense of being and, thus, cannot be reduced to just a predicative or veridical sense of being. -/- 4. Bound Knowledges In addition to KG, the Good is also the basis of another principle in the second Socrates, namely the principle of 'Bound Knowledge' (BK): -/- BK Knowledge of everything is bound to the knowledge of the Good. -/- We distinguished BK from KG because we want to insist, in BK, on what had not been insisted upon in KG, that is, the binding role that the Good plays in the second Socrates, contrasting the absence of such a role in the first Socrates. Socrates remembers, in Phaedo, his wonderful keen on natural philosophers' wisdom when he was young. The origin of this enthusiasm was Socrates’ hope to know the cause of everything as they used to claim. When he was searching the matters of his interest on their basis, Socrates says, he became convinced he can get no acceptable answer from them and found himself blind even to the things he thought he knew before. One day he hears Anaxagoras’ theory that 'it is Mind that arranges and is the cause of everything (ὡς ἄρα νοῦς ἐστιν ὁ διακοσμῶν τε καὶ πάντων αἴτιος)' (Phd. 97c1-2 cf. DK, Fr.15.8-9, 11-12, 12-14) and thinks that he can finally find what he has always expected, i.e. something which can explain all things. What I intend to show here is that what makes Socrates hopeful is that Anaxagoras’ theory tries 1) to explain all things by one thing and 2) this explanation is understood by Socrates as if it is based on the concept of the Good. That Socrates was searching for one explanation for all things can be proved even from what he has been expecting from natural philosophers. The case is, nonetheless, more clearly asserted when he speaks about Anaxagoras’ theory. In addition to διακοσμῶν τε καὶ πάντων αἴτιος of 97c2 mentioned above, we have τὸ τὸν νοῦν εἶναι πάντων αἴτιον (c3-4) and τόν γε νοῦν κοσμοῦντα πάντα κοσμεῖν (c4-5) all emphasizing on the cause of all things (πάντα) which can clearly prove that one of the reasons which caused Socrates to embrace it delightfully was its claim to provide the cause of all things by one thing. Another reason was that Anaxagoras’ Mind, at least in Socrates’ view, was attempting to explain everything by the concept of the Good. This connection between Mind and Good belongs more to the essential relation they have in Socrates’ thinking than Anaxagoras’ theory because there are almost nothing about such a relation in Anaxagoras. The reason for Socrates’ reading can be that Mind is substantially compatible with Socrates’ idea of the relation between good and knowledge. Both the thesis 'no one does wrong willingly' and the theory of virtue as knowledge we pointed to above are evidences of this essential relation. Nobody who knows that something is bad can choose or do it as bad. The reason, when it is reason, that means when it is as it should be, when it is wise or when it knows, works only based on good-choosing. In this context, when Socrates hears that Mind is considered as the cause of everything, it sounds to him like this: good should be regarded as the basis of the explanation of all things. We see him, thus, passing from the former to the latter without any proof. This is done in the second sentence after introducing Mind: -/- I thought that if this were so, the arranging Mind would arrange all things and put each thing in the way that was Best (ὅπῃ ἂν βέλτιστα ἔχῃ). If one then wished to find the cause of each thing by which it either perishes or exists, one needs to find what is the best way (βέλτιστον αὐτῷ ἐστιν) for it to be, or to be acted upon, or to act. On these premises then it befitted a man to investigate only, about this and other things, what is the most excellent (ἄριστον) and best (βέλτιστον). The same man must inevitably also know what is worse (χεῖρον), for that is part of the same knowledge. (97c4-d5) This passage is a good evidence of Socrates’ leap from Anaxagoras’ Mind to his own concept of the Good that can explain why Socrates found Anaxagoras theory after his own heart (97d7). Mind is welcomed because of its capability for explanation on the basis of good to 'explain why it is so of necessity, saying which is better (ἄμεινον), and that it was better (ἄμεινον) to be so' (97e1-3). What Socrates thought he had found in Anaxagoras can indicate what he had been expecting from natural scientists before. Socrates could not be satisfied with their explanations because they were unable to explain how it is the best for everything to be as it is. It can probably be said, then, that it was the lack of the unifying Good in their explanation that had disappointed him. We must insist that we are discussing what Socrates thought that Anaxagoras’ theory of Mind should have been, not about Anaxagoras’ actual way of using Mind. Phaedo 97c-98b, is not about what Socrates found in Anaxagoras but what he thought he could find in it. On the contrary, it should also be noted that it was not this that was dashed at 98b, but Anaxagoras’ actual way of using Mind. It was Anaxagoras’ fault not to find out how to use such an excellent thesis (98b8-c2, cf. 98e-99b). Socrates gives an example to show how not believing in 'good' as the basis of explanation makes people be wanderers between different unreal explanations of a thing. His words δέον συνδεῖν (binding that binds together) as a description for the Good we chose as the name of BK principle: They do not believe that the truly good and binding binds and holds them together (ὡς ἀληθῶς τὸ ἀγαθὸν καὶ δέον συνδεῖν καὶ συνέχειν οὐδὲν οἴονται). (99c5-6) -/- Having in mind Plato’s well-known analogy of the sun and the Good at Republic 508-509, we can dare to say that his warning of the danger of seeing the truth directly like one watching an eclipse of the sun in Phaedo (99d-e) is more about the difficulty of so-called good-based explanation than its insufficiency, a difficulty which is precisely confirmed in Republic (504e-505a, 506d-e). Moreover, BK is asserted in a more explicit way in the Republic, where the Good is considered not only as a condition for the knowledge of X, as was noted above discussing KG, but also as what binds all the objects of knowledge and also the soul in its knowing them. At Republic VI, 508e1-3, when Socrates says that the Form of the Good 'gives truth to the things known and the power to know to the knower (τοῦτο τοίνυν τὸ τὴν ἀλήθειαν παρέχον τοῖς γιγνωσκομένοις καὶ τῷ γιγνώσκοντι τὴν δύναμιν ἀποδιδὸν)', he wants to set the Good at the highest point of his epistemological structure by which all the elements of this structure are bound. This binding aspect of the Good is by no means a simple binding of all knowledges or all the objects of knowledge, but the most complicated kind of binding as it is expected from the author of the Republic. The kind of unity the Good gives to the different knowledges of different things is comparable with the unity which each Form gives to its participants in Republic: as all the participants of a Form are united by referring to the ideas, all different kinds of knowledge are united by referring to the Good. If we observe Aristotle's assertion that for Plato and the believers of Forms, the causative relation of the One with the Forms is the same as that of the Forms with particulars (e.g. Metaphysics 988a10-11, 988b4), that is to say the One is the essence (e.g., ibid, 988a10-11: τοῦ τί ἐστὶν, 988b4-6: τὸ τί ἢν εἶναί) of the Forms besides his statement that for them One is the Good (e.g., ibid, 988b11-13) the relation between the Good and unity may become more understandable. Since the quiddity of the Good (τί ποτ᾽ ἐστὶ τἀγαθὸν) is more than discussion (506d8-e2), we cannot await Socrates to tell us how this binding role is played. All we can expect is to hear from him an analogy by which this unifying role is envisaged, the sun. The kind of unity that the Good gives to the knowledge and its objects in the intelligible realm is comparable to the unity that the sun gives to the sight and its objects in the visible realm (508b-c). The allegory of Line (Republic VI, 509d-511), like that of the Sun, tries to bind all various kinds of knowledges. The hierarchical model of the Line which encompasses all kinds of knowledge from imagination to understanding can clearly be considered as Plato’s effort to bind all kinds of knowledges by a certain unhypothetical principle. The method of hypothesis starts, in the first subsection of the intelligible realm, with a hypothesis that is not directed firstly to a principle but a conclusion (510b4-6). It proceeds, in the other subsection, to a 'principle which is not a hypothesis' (b7) and is called the 'unhypothetical principle of all things' (ἀνυποθέτου ἐπὶ τὴν τοῦ παντὸς ἀρχὴν) (511b6-7). This παντὸς must refer not only to the objects of the intelligible realm but to the sensible objects as well. Plato does posit, therefore, an epistemological principle for all things, a principle that all things are, epistemologically, bound and, thus, unified by. -/- 5. Bound Beings The ontological aspect of BK we shall call the principle of 'Bound Beings' (BB): -/- BB Being of all things are bound by the Good. -/- We saw in our principle of Split Being (SB) how the first Socrates was criticized because of his approach to split being and separate each thing from other things. The principle of Bound Beings intends to make the things more related, a duty which is done again by the Good. In the allegory of Sun, there are two paragraphs that evidently and deliberately extend the binding role of the Good to the ontological scene: -/- You will say that the sun not only makes the visible things have the ability of being seen but also coming to be, growth and nourishment. (509b2-4) -/- This clearly intends to remind the ontological role the sun plays in bringing to being all the sensible things in order to display how its counterpart has the same role in the intelligible realm (b6-10): -/- Not only the objects of knowledge (γιγνωσκομένοις) owe their being known (γιγνώσκεσθαι) to the Good, but also their existence (τὸ εἶναί) and their being (οὐσίαν) are due to it, though the Good is not being but superior to it in rank and power. That the Good is here represented as responsible for being of things in addition to their being known means, in my opinion, that Plato wants to posit BB in addition to BK. The allegory of Cave at the very beginning of the seventh Book (514aff.) can be taken as another evidence. The role of the Good, one might say, is confined to the intelligible realm because it is asserted that the role the Good plays in this realm is corresponding to that of the sun in the visible realm. The fact that Plato wants to observe the Good also as the ontological cause of the sensible things is obvious from his saying, in the allegory of Cave, that the Form of the Good 'produces light and its source (τὸν τούτου κύριον) [i.e. the sun] in the visible realm' (517c3). We can conclude, then, that the ontological function of the Good is not confined to the intelligible realm in which it is the lord and provides truth and understanding (c3-4) because it is also responsible to produce τὸν κύριον of light. 6. Proportionality of Being and Knowledge Insofaras BE and BO principles of the first Socrates gave way to TE and TO principles of the second Socrates, we cannot expect him to preserve KB in the same way as it was in the first Socrates. The new tripartite ontology and epistemology necessitates some modifications in KB which results in the principle of 'Proportionality of Being and Knowledge' (PBK): -/- PBK To every class of being there is a proportionate category of knowledge. -/- This principle, of course, does not entail the refutation of KB and thus is not kind of rejecting PBK but only a more complicated version of it. Based on PBK, we can still agree that knowledge is of being (KB) but the issue is that since none of the concepts of knowledge and being in the second Socrates are as simple as they were for the first Socrates, we need a more complicated principle for their relation here. Although from Meno 97a where the distinction of knowledge and true opinion is drawn out in the second group of the dialogues, we can expect a new relation, it is articulated in its most complete way in Republic and specifically in the allegory of Line. All the beings are divided there hierarchically to four classes, to each of them belongs a class of knowledge: imagination to images, belief to the sensible things (more correctly: the things of which they[in previous class] were images (ᾧ τοῦτο ἔοικεν)), thought to mathematical objects (?) and understanding to the Forms and the first principle. The degree of clarity that each of the classes of knowledge shares in (σαφηνείας ἡγησάμενος μετέχειν) is proportionate to the degree that its object shares in truth (ἀληθείας μετέχει). (511e2-4) -/- Conclusion From the six onto-epistemilogical principles of the first Socrates, four principles turn to their opposite in the middle period dialogues. While bipolar epistemology and ontology of the early dialogues give place to tripartite epistemology in the middle period dialogues and tripartite ontology in Republic, the split knowledge and being of the first Socrates are inclined to be substituted by bound knowledges and bound beings in the second Socrates and specifically in Republic. Not all our system of principles in this article is necessarily determinative. Either they are rightly formulated or not, our result would not be vulnerable if we accept that 1) making the distinction of knowledge and belief, 2) accepting the being of not being and 3) trying to bind both being and knowledge by the concept of the Good happens only in middle period dialogues, having been absent in the early ones. These are the favourite results all those somehow arbitrary and even oversimplified principles were to illustrate; that there is kind of a development in the epistemological as well as the ontological grounds of Plato’s philosophy. -/- Notes . (shrink)

OBJETIVO A gestação nos mamíferos domésticos é um processo fisiológico que implica mudanças físicas, metabólicas e hormonais na fêmea, que culminam com o nascimento de um novo indivíduo. Desta forma, a compreensão de tais mudanças e como estas favorecem um ambiente ideal de desenvolvimento embrionário inicial, até a placentação e a fisiologia envolvidas durante esses processos é fundamental na tomada de decisões quanto à saúde reprodutiva da fêmea, na seleção de futuras matrizes e até mesmo para a saúde fetal e (...) sanidade do novo animal. Neste capítulo, o estudante compreenderá de forma clara, concisa, didática e objetiva, as adaptações maternas e fetais para o estabelecimento da gestação após a fecundação, o desenvolvimento desta e também identificará as diferenças existentes entre as espécies de interesse zootécnico. INTRODUÇÃO O estabelecimento da gestação nos mamíferos domésticos inclui três etapas fundamentais: o reconhecimento materno da gestação ou prenhez (RMP), a implantação e a placentação. Dentro da fisiologia da reprodução nos mamíferos, a implantação e a placenta- ção constituem processos essenciais na nutrição do embrião e do feto e, portanto, para seu desenvolvimento; devido a isso, são etapas críticas para a produção animal já que possuem um efeito direto sobre a eficiência reprodutiva. Nos bovinos leiteiros, por exemplo, estima-se uma taxa de fertilização perto de 95%, embora apenas 55% desses zigotos se desenvolvam e cheguem ao parto, o qual representa uma perda de gestações perto de 35%. Entre 70% e 80% das mortes embrionárias ocorrem durante as três semanas seguintes à ovulação, o que coincide com o período no qual se estabelecem os processos de implantação e placentação supracitados. O desenvolvimento embrionário precoce depende da sincronia de eventos entre o oviduto-útero e o embrião. Foi determinado que a presença do embrião pode modificar as secreções ovidutais e uterinas durante as fases iniciais de desenvolvimento. O ambiente endócrino materno (predominância de progesterona) também modula as características das secreções ovidutais e uterinas para assegurar a sobrevivência embrionária no caso da fertilização ter sido bem sucedida. Se este último ocorrer, então o embrião deverá indicar à mãe a sua existência para que sejam mantidas as condições adequadas ao seu desenvolvimento. Como supracitado, o embrião em seu curso pelo oviduto requer certas secreções para sobreviver e desenvolver-se, no entanto, graças à fertilização in vitro, têm-se dispensado a importância das secreções ovidutais, já que se observou que um embrião é capaz de se desenvolver em condições laboratoriais fora do aparelho reprodutor materno durante as suas fases iniciais, e consegue estabelecer uma gestação normal que chega a termo após a sua reintrodução no útero. Em estágios mais tardios de desenvolvimento o embrião necessita necessariamente do meio uterino para sobreviver e continuar o seu crescimento. No bovino, por exemplo, o embrião só é capaz de alongar-se estando dentro do útero, indicando a presença de fatores específicos necessários para que o embrião se desenvolva de maneira normal. Um meio endócrino no qual predomina a progesterona materna durante a gestação induz a secreção do histiotrofo (ou leite uterino) que permite a nutrição e a sobrevivência do embrião antes da implantação e da formação da placenta, através do qual obterá a maioria do fornecimento e intercâmbio necessários para continuar o seu desenvolvimento intra-uterino. SEGMENTAÇÃO E DESENVOLVIMENTO EMBRIONÁRIO PRECOCE O desenvolvimento embrionário precoce, conhecido como período de pré- -implantação, é essencial; inclui processos de divisão e diferenciação celular que são realizadas no início com uma elevada sincronização para garantir o desenvolvimento correto do indivíduo dentro do útero. Esta fase envolve a passagem do zigoto (unicelular), a embrião (multicelular) e, por fim, em concepto (quando se distingue o embrião com suas membranas extraembrionárias). O desenvolvimento precoce é o estágio mais dinâmico e vulnerável na formação de um indivíduo. Investigações recentes demonstraram que alterações nesta etapa podem modificar características produtivas ou reprodutivas durante a vida adulta. É por isso que é necessário conhecer as etapas fisiologicamente normais envolvidas neste processo (figura 1). Em fases mais tardias de desenvolvimento, o embrião se converterá em um feto com todos os sistemas e tecidos diferenciados observados num animal adulto. Após a fertilização, o zigoto resultante é capaz de dar origem a um novo organismo completo, de modo que se considera como uma célula totipotencial. O desenvolvimento embrionário começa e se consegue graças a uma série de divisões mitóticas conhecidas como segmentação ou clivagem (cleavage, em inglês). A primeira divisão mitótica dá origem a duas células filhas idênticas (figura 1), e ocorre por volta das 20 às 30 horas depois da fertilização, com divisões subsequentes a cada 12 a 24 h, dependendo da espécie. As células resultantes destas divisões são conhecidas como blastômeros. A orientação da divisão inicial que dá origem aos dois primeiros blastô- meros, parece ser guiada pela posição dos corpos polares. As divisões iniciais das células embrionárias são sincrônicas, no entanto, conforme o desenvolvimento se torna assincrônicas. Assim, a divisão mitótica inicial dá origem a um embrião de duas células (dois blastômeros), a segunda a um embrião de quatro células, a terceira a um de oito células e a quarta a um com 16 células, onde passa a ser chamado de mórula. Estas divisões são realizadas sem o aumento do volume do citoplasma, para que seja restabelecida uma proporção celular mais adequada à das células somáticas, já que o ovócito é a célula mais grande do organismo (um ovócito mede entre 100 e 150 μm do ovócito, enquanto uma célula somática mede de 10 a 20 μm); e porque o embrião ainda está contido dentro da zona pelúcida (figura 1). Um dos pontos críticos durante o desenvolvimento embrionário precoce é a ativação do genoma embrionário. Durante as etapas iniciais após a fertilização, as proteínas e RNAs “herdados” do ovócito são responsáveis pelo metabolismo e desenvolvimento inicial do embrião. É apenas até o estágio de quatro (ratos) ou oito blastômeros (espécies domésticas e humanas) em que o embrião começa a sintetizar o seu próprio RNAm (mensageiro) e as proteínas específicas necessárias para controlar o seu crescimento e metabolismo. A qualidade do ovócito que é fertilizado, consequente- mente, tem um grande impacto sobre a sobrevivência inicial do embrião. Quando o embrião atinge uma média de 16 a 32 células é conhecido como mórula (tabela 1) (do latim morus: mora), e nesta fase o embrião começa a compactar-se, o que ocorre porque começam a estabelecer-se diferentes uniões celulares, de acordo com a relação espacial entre os blastômeros. As células centrais desenvolvem-se incluindo entre elas junções comunicantes, conhecidas também como junções GAP, enquanto as que se encontram na periferia estabelecem uniões estreitas, dando origem a duas subpopulações distintas de blastômeros: periféricos e centrais. Cabe mencionar que os blastômeros que compõem a mórula ainda são células capazes de dar origem a um novo indivíduo completo, ou seja, são totipotenciais. À medida que a mórula continua a dividir-se e a crescer, as células localizadas na periferia começam a liberar sódio para os espaços intercelulares, criando uma diferença na pressão osmótica seguida pela entrada de água ao embrião. O líquido se acumula e provoca a separação das células, distinguindo ainda mais as duas subpopulações de células mencionadas (periféricas e centrais) e forma-se uma cavidade cheia de líquido. Esta cavidade é conhecida como blastocele; com a sua formação o embrião entra em fase de blastocisto (figura 1, tabela 1). Da subpopulação celular da periferia se origina do trofoblasto (trofoectoderma) que formará a maioria das membranas extraembrionárias (placenta), e da subpopulação central é estabelecida a massa celular interna ou embrioblasto, que dará origem ao embrião propriamente dito, ou seja, ao feto. Ao continuar a multiplicação e crescimento do trofoblasto à medida que o blastocisto se desenvolve, as células da massa interna se diferenciam novamente em dois segmentos distintos: a endoderme primitiva ou hipoblasto e o epiblasto (figura 1), em que todos os tecidos do organismo (saco vitelino) são originados e as células germinativas primordiais. Uma vez formado, o epiblasto continua a dividir-se e a diferenciar-se para dar origem às três placas ou camadas germinativas conhecidas como endoderme, mesoderme e ectoderme. Este processo é conhecido como gastrulação, e durante este diferem-se no embrião as porções craniais, caudais, dorsais e ventrais, processo conhecido como polaridade do embrião, que orienta o desenvolvimento dos diversos tecidos e órgãos do indivíduo. À medida que o blastocisto continua crescendo e diferenciando-se, vai-se acumulando mais líquido no blastocele, com o que a pressão interna aumenta e a zona pelúcida começa a ficar mais fina. Este fato, juntamente com a ação de proteases produzidas pelo embrião, leva à ruptura da zona pelúcida e à saída do blastocisto (eclosão), pelo que, uma vez liberado, o embrião é conhecido como blastocisto eclodido. O trofoblasto embrionário entra, então, em contato direto com o endométrio, o que é considerado como o início da implantação. IMPLANTAÇÃO O trofoblasto embrionário, também conhecido como trofoectoderma, dá origem à maioria das membranas fetais ou placenta fetal. O processo no qual o trofoblasto se une ao endométrio materno é conhecido como implantação; para isso ocorre uma série de processos altamente sincronizados envolvendo secreções embrionárias e maternas, e interações físicas, durante um período limitado conhecido como janela de receptividade. A implantação é considerada um processo gradual que genericamente se divide em cinco fases, algumas das quais podem sobrepor-se parcialmente e diferir segundo a espécie: 1. Eclosão do blastocisto da zona pelúcida (figura 2); -/- 2. Pré-contato e orientação do blastocisto. É o contato inicial entre as células do trofoblasto e do epitélio endometrial, bem como a orientação da massa celular interna e do trofoectoderma, que assume especial importância em espécies cuja implantação é invasiva, como em roedores e primatas; 3. Aposição - refere-se ao posicionamento do blastocisto numa determinada área e de uma forma específica no útero. Começa a interdigitação das vilosidades coriônicas com o epitélio luminal do endométrio. 4. Adesão - requer sistemas de sinalização que envolvem glicoproteínas de adesão, como integrinas, selectinas e galectinas, com os seus ligantes, tanto no epitélio luminal como no epitélio trofoectoderma. 5. Invasão endometrial - este termo se relaciona ao tipo de placentação e é pertinente sobretudo para aquelas espécies onde existe uma fusão entre células do trofoblasto e do epitélio do endométrio durante a formação da placenta, ou que as células trofoblásticas penetrem as camadas endometriais e até modifiquem as células do endométrio que as rodeiam. Existem três tipos de implantação ou nidação. Na nidação central ou não invasiva, a vesícula embrionária ocupa uma posição central na luz do útero e, na sua relação com a mucosa uterina, unicamente através das vilosidades coriônicas (projeções das células trofoblásticas dentro das quais crescem capilares do feto), há adesão mas não invasão da mucosa. Este tipo ocorre nos ungulados domésticos, mas não em carnívoros. Na nidação excêntrica a vesícula embrionária está inserida num canal profundo da mucosa, parcialmente isolada da luz principal, e se apresenta na rata, cadela e gata. A nidação intersticial é própria dos primatas, rato e cobaia, e nesta produz-se a destruição do epitélio e do tecido conjuntivo do útero, de modo que a vesícula embrionária se afunda na própria lâmina mucosa e se desenvolve em um espaço intersticial. Até o momento da implantação, a nutrição do embrião é histotrófica, sendo as substâncias necessárias absorvidas através do trofoblasto, como foi mencionado anteriormente. A partir deste momento, o trofoblasto começa o desenvolvimento de uma série de membranas extraembrionárias que permitirão finalmente a troca de nutrientes e metabólitos entre o sangue materno e o do embrião, constituindo a placenta. Um fato necessário na implantação é a perda de receptores para progesterona no epitélio luminal do endométrio, e pré-sensibilização do mesmo pelos estrógenos. Apesar de parecer um efeito contraditório, este requisito permite o desaparecimento de uma camada de mucina e outros compostos proteicos, que revestem o endométrio e que atuam como uma película antiaderente que inicialmente não permite a aposição e adesão do embrião. O desaparecimento desta camada ocorre durante a janela de receptividade, seja em toda a superfície do endométrio (ruminantes, suínos e roedores) ou nas zonas específicas onde o blastocisto será implantado (humano e coelho). Por esta razão, a interação física entre o embrião e o endométrio desempenha um papel importante na implantação. Uma vez que a camada de glicoproteínas desaparecer, é possível a aposição do trofoectoderma embrionário e das células epiteliais do endométrio, iniciando assim a implantação propriamente dita através da intercomunicação entre os dois tecidos. A implantação pode ser considerada como a fixação do embrião ao útero a partir do ponto de vista físico e funcional. No entanto, como se trata de um processo progressivo e gradual, em que algumas das suas fases podem ser parcialmente sobrepostas, não existe consenso sobre o período em que se inicia e termina. Na borrega, por exemplo, estima-se que ocorra entre o dia 10 e o dia 22, enquanto na vaca entre os dias 11 e 40 pós-ovulação. Nas espécies polítocas, isto é, fêmeas que parem várias crias como as porcas, os blastocistos se distribuem ao longo dos cornos uterinos como resultado de movimentos musculares da parede uterina, aparentemente regulados por prostaglandinas e outros fatores secretados pelo útero. Por exemplo, nas porcas, os blastocistos se movem livremente entre os cornos, e a distribuição dos embriões ao implantar-se é mais uniforme do que poderia ser esperado se ocorresse meramente ao acaso. Tem observado que a deficiência na produção de ácido lisofosfatídico 3 (LPA3) e/ou seu receptor, ocasiona uma falha na distribuição dos embriões no útero. Por outro lado, não há evidência de que um blastocisto implantado exerça alguma influência inibitória sobre a implantação de outro blastocisto próximo a ele. Como supracitado, o processo de implantação inclui uma complexa interação entre o embrião e o útero, e cada um deles provê de estímulos essenciais para favorecer a progressão do outro, apresentando-se diferenças em tempos e particularidades dentro das diferentes espécies. -/- Porca O período de adesão situa-se entre os dias 12 e 24 após a fertilização. Ao redor do dia sete, o blastocisto é eclodido, porque o trofoblasto está em contato direto com o epitélio uterino e começa a proliferar com rapidez. O endoderme se forma e o blastocisto muda de uma pequena vesícula esférica para um tubo muito alongado que chega a medir cerca de um metro em poucos dias, ele que lhe proporciona uma superfície muito ampla para a absorção de nutrientes. Cadela Os embriões migram entre os dois cornos uterinos do dia 12 ao 17 após a fertilização, distribuindo-se de maneira uniforme. Estes embriões aderem ao endométrio entre os dias 16 e 18, e alcançam sua implantação final entre o dia 17 e 20 da gestação. Cabe ressaltar que nos caninos o período de pré-implantação é o mais longo das espécies domésticas, o que ocorre porque a cadela ovula ovócitos imaturos (ovócitos primários) que precisam amadurecer por dois a três dias, para formar ovócitos secundários, antes que a fertilização seja possível. Por isso, o zigoto canino chega à junção útero-tubárica entre o sétimo e o décimo dia após o pico pré-ovulatório de LH (a ovulação ocorre, em média, dois dias após o pico de LH), entrando no útero em estágio de mórula ou blastocisto em torno dos dias 10 a 12 depois do referido pico. Ovelha O desenvolvimento precoce do blastocisto é muito semelhante ao da porca. Observa-se certo grau de adesão desde o dia 10 da gestação, mas o alongamento do embrião é menos extenso do que em suínos e tem início entre o dia 11 e 12. Para a terceira semana o embrião ovino chega a medir até 30 cm de comprimento. O processo de implantação é concluído aproximadamente entre a quarta e quinta semana de gestação (figura 3). Vaca O processo de implantação é semelhante ao da borrega, mas tem início mais tarde. A zona pelúcida se perde por volta do dia 9 a 10 (blastocisto eclodido) e o embrião começa a alongar-se ao redor do dia 12 a 14, atingindo um comprimento de cerca de 60 mm para o dia 16, embora possa haver uma grande variação individual. A partir do dia 33, o córion é formado e existe uma adesão inicial que inclui dois ou quatro cotilédones, que se interdigitam rapidamente com o tecido materno de modo que o embrião começa a nutrir-se através deles. Égua O blastocisto atinge um diâmetro de cinco centímetros aos dois meses e pratica- mente não se alonga. Entre os dias seis e sete após a ovulação, o embrião começa a revestir-se de uma camada glicoproteica que se forma entre o trofoectoderma e a zona pelúcida e que contém e mantém o embrião esférico depois de ter eclodido. Esta cápsula é uma estrutura única nos equinos (cápsula embrionária), afina-se no dia 18 e se perde entre os dias 21 e 23 de gestação. Na décima semana as microvilosidades do córion se interdigitam com a mucosa da parede uterina e na semana 14 é completada a implantação. Espécies não domésticas Em algumas espécies como os marsupiais, os ursos, focas, doninhas e alguns tipos de cervídeos, pode interromper-se temporariamente o desenvolvimento do embrião in utero e adiar a sua implantação, como estratégia evolutiva para favorecer o nascimento das crias em condições ambientais favoráveis para a sua sobrevivência. Esta estratégia é conhecida como diapausa e pode ser uma condição obrigatória ou facultativa para cada gestação, dependendo da espécie. Os mecanismos que a desencadeiam e a concluem não estão totalmente explicados e são espécie-específica. RECONHECIMENTO MATERNO DA GESTAÇÃO (RMG/RMP) O estabelecimento da gestação em mamíferos domésticos requer a presença de um corpo lúteo CL funcional que produz progesterona em quantidades adequadas para manter o desenvolvimento embrionário inicial e permitir mudanças necessárias durante o período de peri-implantação. Para que o corpo lúteo seja mantido e a fêmea seja impedida de reiniciar um novo ciclo estral, o embrião deve sinalizar sua presença para a mãe. O sinal para o reconhecimento materno da gestação (RMG) provém então do embrião e podem ser de dois tipos: luteotrópico ou anti-luteolítico. No primeiro, a(s) substância(s) produzida(s) pelo embrião que atua(am) sobre o corpo lúteo para manter sua funcionalidade, por exemplo a gonadotrofina coriônica humana (hCG) e a prolactina em roedores. O segundo tipo de sinal previne ativamente a luteólise, e é o mecanismo presente nas espécies domésticas em que o embrião produz substâncias como o interferon-τ (IFN-τ) em ruminantes ou os estrógenos em suínos. Ruminantes Como supracitado, o IFN-τ é responsável pela sinalização para o reconhecimen- to materno da gestação neste grupo que engloba cabras, ovelhas e vacas (figura 4). É um fator produzido pelas células do trofoblasto do embrião, e pode ser detectado a partir dos dias 11 a 12 em ovinos e de 14 a 15 em bovinos. Uma vez secretado, o IFN-τ impede a lise do corpo lúteo (efeito anti-luteolítico) por meio do bloqueio indireto da síntese de prostaglandina F2 alfa (PGF2α). No trabalho acerca do ciclo estral foi explicado que a luteólise requer a presença de receptores de ocitocina (OTR) no endométrio, que ao unir-se ao seu ligante, a ocitocina (proveniente inicialmente do hipotálamo e posteriormente de origem lútea), estimulam a produção de PGF2α e estabelecem um feedback positivo, que culminará na destruição do CL. Para que os OTRs sejam sintetizados, é necessária uma estimulação prévia do endométrio com estradiol, que ocorre através da ligação com seus receptores (ER-1). O mecanismo pelo qual o IFN-τ impede a lise do corpo lúteo é bloqueando, direta ou indiretamente, a síntese de OTR e, consequentemente, a produção pulsátil de PGF2α. Suínos No caso dos suínos, considera-se que o sinal embrionário para o reconhecimento materno da gestação são os estrógenos, produzidos pelos embriões em torno do dia 11 a 12 pós-ovulação. O endométrio suíno produz PGF2α que, quando não há gestação, é secretado na circulação uterina (secreção endócrina), de onde é transportada em direção ao CL para causar luteólise. Se há embriões no útero produzindo suficiente quantidades de estradiol, isso redireciona a secreção de PGF2α para o lúmen uterino (secreção exócrina), evitando que seja liberado para a circulação e, portanto, é sequestrado impedindo que chegue ao corpo lúteo (figura 5). É importante enfatizar que a produção de PGF2α não é inibida, mas sua secreção é redirecionada. Este mecanismo é conhecido como teoria endócrino-exócrina. Vale ressaltar que para o sinal de reconhecimento materno da gestação na porca ser eficiente, é necessário a presença de pelo menos quatro embriões, dois em cada corno, uma vez que se não houver dois embriões, um em cada corno, ocorre luteólise e reinicia a atividade cíclica. Embora os estrógenos sejam identificados como o sinal de reconhecimento materno nesta espécie, o embrião suíno também produz outros fatores, como a PGE2 e o ácido lisofosfatídico, considerado necessário para o estabelecimento adequado da gestação. A PGE2 ocasiona uma redução na produção de PGF2α em favor da PGE2 no endométrio e favorece a contração do miométrio para permitir a migração de embriões. O ácido lisofosfatídico, juntamente com seu receptor, é um fator crítico que favorece a migração intra-uterina, e permite uma distribuição adequada dos embriões ao longo dos cornos. Outras substâncias produzidas pelo embrião suíno são o IFN-delta (IFN-δ) e IFN-gama (IFN-γ), que não possuem ação anti-luteolítica, mas poderiam intervir no processo de implantação. Equinos Na égua é essencial que o embrião, ainda rodeado pela sua cápsula embrionária, migre de 12 a 14 vezes por dia através do útero, entre os dias 12 e 14 após ovulação, a fim de distribuir o fator de reconhecimento materno (figura 6). Embora seja sabido que existe, este último ainda não foi identificado, mas foi estabelecido que é da natureza proteica e seu principal efeito é a inibição da produção endometrial de PGF₂α, mediante a redução na formação do receptores de ocitocina; desta forma, evita-se o início do sinal luteolítico. É interessante notar que nesta espécie a ocitocina não é de origem lútea e sim endometrial. Primatas Ao contrário das espécies domésticas mencionadas, o mecanismo de ação do sinal de reconhecimento materno em primatas é luteotrópico. No humano, o embrião produz gonadotrofina coriônica humana (hCG) após o início da implantação (dias 6 a 8). A hCG estende a vida funcional do CL por meio de sua ligação a receptores lúteos para LH, estimulando assim a liberação de progesterona. Este efeito permite a “sobrevivência” do CL pelo menos até o momento em que a produção de progesterona é transferida para a placenta para levar a gestação a termo. Carnívoros Na cadela não é necessário o reconhecimento da gestação, já que normalmente o corpo lúteo tem uma vida média maior que a duração da gestação. Como na égua, a migração dos embriões através do útero antes da implantação pode favorecer o reconhecimento materno. Adicionalmente, tem sido descrito que durante o período antes da implantação (< 10 dias depois da ovulação), há um aumento na expressão de genes relacionados com a imunomodulação local (IFN-γ, IL-4 e CD8+), que não estão presentes em cadelas durante o diestro. A produção de IFN-γ por parte do embrião canino, como em outras espécies, pode estar envolvida na implantação ou o reconheci- mento da gestação, mas até o momento não foi demonstrado de forma inequívoca. Na gata doméstica, o fator que favorece o reconhecimento materno da gestação ainda não foi descrito. Temos que lembrar que seja qual for o mecanismo envolvido, a produção do sinal embrionário de reconhecimento materno da gestação é importante, já que a contínua presença de progesterona na circulação materna, faz possível que ocorra o desenvolvimento precoce do embrião e eventualmente a implantação, com a formação do órgão temporal mais importante para o desenvolvimento fetal: a placenta. Resumindo, o sinal enviado pelo embrião deve ser dado antes do útero começar a secretar PGF2a, hormônio que causa a destruição do corpo lúteo produtor da progesterona necessária para a gestação. O embrião deve secretar algumas substâncias (denominadas EPF: Early Pregnant Factors/fatores de gestação precoce) que capte o endométrio materno e sirva para evitar a ação luteolítica da PGF2a. Na porca, em vez de ser evitada a secreção de PGF2a, o referido hormônio é “sequestrado na luz do útero” e, desta forma, passa a secretar-se em forma exócrina, sem ter efeito sobre o corpo lúteo. No bovino, o reconhecimento materno da gestação é o processo fisiológico no qual o embrião, por meio de sinais moleculares como a secreção de interferon-τ (IFN-τ), anuncia sua presença no trato reprodutivo materno a fim de evitar que seja desencadeado o mecanismo luteolítico exercido pela PGF2a sobre o corpo lúteo. PLACENTAÇÃO Nos mamíferos domésticos, o processo de implantação é gradual e prolongado, e ocorre paralelamente a processos como a gastrulação e a formação de membranas extra- embrionárias: saco vitelino, âmnio, alantóides e córion. A formação das membranas extraembrionárias nos mamíferos eutérios, ou seja, aqueles que formam uma placenta completa, é um processo indispensável que permite ao embrião aderir-se ou implantar-se ao endométrio materno. As quatro membranas extraembrionárias mencionadas são formadas a partir do trofoblasto, mesoderme e endoderme embrionários. O saco vitelino fornece nutrientes no desenvolvimento inicial do embrião e se converte em vestigial quando a gestação progride; tem origem no endoderma primitivo, estrutura que junta com o trofoblasto e o mesoderma, formam o córion e âmnions. O âmnion contém o líquido amniótico que está em contato direto com o embrião e é a membrana mais interna; ademais, protege o feto, proporciona lubrificação para o parto e serve como um depósito para urina e resíduos fetais. O córion, por outro lado, é a membrana mais externa do embrião e, portanto, é a que entra em contato direto com o endométrio uterino materno; se fixa ao útero, absorve nutrientes do útero, permite a troca gasosa materno/fetal e produz hormônios. O alantóide se origina de uma evaginação do intestino primitivo e é de onde surge o sistema vascular da placenta fetal; a fusão com o córion (placenta cotiledonária), carrega os vasos sanguíneos do cordão umbilical, que liga o feto com o alantóide e é um reservatório de nutrientes e resíduos. Conforme o embrião se desenvolve, o saco vitelino regride e o alantóide se enche de líquido, pelo que este último se funde com o córion para formar o corioalantóides, que se torna a membrana mais externa e, portanto, a porção fetal do placenta. A placenta é um órgão temporário que representa uma interface através da qual realiza a troca bidirecional de nutrientes, gases, hormônios e outras substâncias entre a mãe e o feto. A unidade funcional da placenta são as vilosidades corioalantóicas, as quais são projeções pequenas dos corioalantóides que se interdigitam com o endométrio uterino, cuja superfície de absorção permite essa troca. A placenta é um órgão endócrino capaz de produzir uma gama de hormônios que ajudam a controlar o ambiente uterino, favorecendo o desenvolvimento do feto, além disso possui um papel importante no momento do parto. Nas diferentes espécies a placenta tem características particulares, pelo qual existem várias classificações, de acordo com a sua posição uterina, a distribuição das vilosidades corioalantóicas e a sua histologia. Posição uterina Refere-se à posição do concepto em relação ao lúmen uterino (figura 7). Central: O concepto ao ser implantado permanece em contato com o lúmen do útero. A maioria das espécies domésticas de importância veterinária estão dentro desta classificação. Excêntrica: O concepto penetra parcialmente o endométrio materno, mas mantém um certo contato com o lúmen uterino. Os roedores (ratos e ratos) e a coelha possuem este tipo de placentação. Intersticial: O embrião invade o endométrio, perde contato com o lúmen uterino, e ao crescer o lúmen uterino se oblitera. Os humanos e a maioria dos primatas mostram este tipo de placenta. Distribuição das vilosidades As vilosidades que formam a interface materno-fetal podem estar distribuídas de maneira diferente ao longo da superfície dos corioalantóides, pelo qual a placenta pode ser classificada como (figura 8): Difusa: Neste tipo de placenta as vilosidades estão distribuídas ao comprimento de toda a superfície do córion (corioalantóides) de maneira uniforme. As placentas de suínos e equinos se enquadram nesta classificação, embora, nesta última espécie, as vilosidades formem estruturas mais ramificadas, que são chamadas microcotilédones (figura 10). Zonal: Esta placenta se apresenta nos carnívoros domésticos, tanto caninos como felinos. As vilosidades que determinam a zona de troca de nutrientes e resíduos, e de ligação com o endométrio são delimitadas de forma a formar uma cintura central em torno do feto (figura 9). Distingue-se também uma segunda região chamada paraplacenta, que se localiza em ambos lados deste “cinto”, e do qual a função não é inteiramente conhecida, embora sabe-se que desempenha um papel importante na troca de ferro da mãe para o feto. As extremidades laterais dos corioalantóides nestas placentas não possuem vilosidades por isso não se ligam ao endométrio. Uma terceira região é a zona transparente nas extremidades distais do córion que tem pouca vascularização. Esta zona pode estar envolvida na absorção de materiais diretamente do lúmen uterino (figura 11). Cotiledonária: É o tipo de placentação que se encontra presente nos ruminantes (ovinos, caprinos e bovinos). As vilosidades coriônicas nestas espécies são agrupadas em pequenas áreas do córion chamadas cotilédones, que se interdigitam e fundem-se parcialmente com locais delimitados no endométrio chamados carúnculas, formando, em conjunto, estruturas conhecidas como placentomas. Cabe destacar que as carúnculas carecem de glândulas endometriais, que só estão presentes nas porções inter-carun- culares do endométrio. Os placentomas, por sua vez, são altamente vascularizados e são remodelados com o progresso da gestação, ramificando-se para aumentar a superfície de troca e o fluxo sanguíneo para aumentar os requisitos do feto em crescimento. Nas zonas inter-carunculares, a placenta é ligada ao endométrio por meio de sistemas de adesão superficial que envolvem glicoproteínas. Acredita-se que a adesão do concepto com o endométrio (carúnculas) é estabelecida em torno de 30 dias em ovinos e 40 dias em bovinos. (figuras 13 a 17). Discoidal: Nestas placentas, as vilosidades agrupam-se numa área circular ou oval, formando uma estrutura discoidal. Este tipo de placenta é encontrada principal- mente em coelhas, roedores e primatas, incluindo os humanos. Histologicamente Esta classificação considera o número de camadas de tecido que compõem a placenta e que separam a circulação materna da circulação fetal (tabela 3). O número máximo é de seis camadas, três do lado fetal (córion, tecido intersticial e endotélio do vaso sanguíneo) e três do lado materno (epitélio endometrial, tecido intersticial e endotélio vascular) (figura 19 e tabela 3). O modo de distinguir e nomear os diferentes tipos de placenta nesta classificação é usando como prefixo a camada materna que está em contato com o córion fetal. As diferentes placentas baseados em sua histologia são as seguintes (figura 19): Epiteliocorial: É o menos íntimo entre os tipos de placentas (figura 20). Estas placentas conservam intactas as seis camadas de tecido, portanto que mantêm as circulações materna e fetal mais separadas, e consideradas como as mais impermeáveis. Este tipo de placenta está presente na porca e égua. Lembre-se de que as placentas da porca e da égua são diferentes e as vilosidades ocupam uma grande proporção da área de superfície do córion (figura 19 A). Também apresenta-se nos ruminantes, no entanto, as placentas dos ruminantes apresentam algumas características particulares que as colocam como um subgrupo e se chamam sinepiteliocorial ou sindesmocorial (figura 19 B). Na vaca, este tipo apresenta-se nos primeiros 2-3 meses de gestação. Além da característica de erosão parcial do epitélio endometrial, um tipo de célula único é encontrado na placenta de ruminantes. Essas células são chamadas células gigantes binucleadas. Como o nome indica, elas são caracterizadas como bastante grandes e com dois núcleos. Na placenta dos ruminantes, algumas células do epitélio coriônico conhecidas como células binucleadas, se fundem com algumas células do epitélio endometrial, criando inicialmente células gigantes trinucleadas e mais tarde placas ou sincícios multinucleados. Estes sincícios têm em consequência uma origem tanto fetal como materna, que criam lugares delimitados nos quais em vez de existir intacta uma camada de epitélio coriônico e outra de epitélio endometrial, encontra-se uma só camada que combina as duas origens. As células gigantes binucleadas migram e mudam seu número ao longo da gestação em forma dinâmica. Este tipo celular é importante porque secretam uma variedade de hormônios. Células gigantes binucleadas aparecem por volta do dia 14 na ovelha e entre os dias 18 e 20 na vaca. Endoteliocorial: 5 camadas. Neste tipo de placentação o córion fetal está em contato direto com o endotélio vascular do endométrio graças à erosão do epitélio e do tecido conectivo endometrial (tecido intersticial) durante a implantação (figura 19 C). De modo que o intercâmbio de substâncias e resíduos só requer atravessar quatro camadas de tecidos. Este tipo de placenta é presente principalmente em cães e felinos. Nota-se nas figuras 19 C e 21 que este tipo de placenta é mais íntimo do que a placenta epiteliocorial porque o epitélio endometrial não existe mais. Hemocorial: 3 camadas (figura 22). Aqui o epitélio coriônico está intacto e entra em contato direto com o sangue materno em regiões onde formam reservatórios de sangue semelhantes a poços (figura 19 D). O intercâmbio de substâncias e resíduos entre a mãe e o feto é mais direto uma vez que é necessário atravessar apenas três camadas para chegar até à circulação fetal. Algumas espécies de primatas, incluindo o ser humano e os roedores possuem este tipo de placentação. MEMBRANAS EXTRAEMBRIONÁRIAS EM AVES Ao mesmo tempo que se estabelece o corpo embrionário e os esboços de cada um dos órgãos começam a gerar-se, torna-se imperioso garantir a sobrevivência do embrião. Tenha-se em conta que nas aves todo o necessário para o desenvolvimento é encontrado no ovo pelo que deve-se reforçar a eficácia das estruturas criadas para garantir o objetivo a que se destina. O exterior é fornecido apenas com o O2; emite CO2 e vapor de água no exterior (perda de 15% da água durante a incubação inicial). Além disso, o neonato não é imaturo, como nos anfíbios, mas está em um estádio maduro juvenil. Como indicado, são quatro as problemáticas a que deve fazer frente o embrião: prover-se de um meio que garanta o desenvolvimento volumétrico, amortecendo os movimentos físicos excessivos que possam traumatizá-lo e evitar a dessecação; assegurar que os nutrientes (vitelo e albúmen) sejam incorporados de forma correta no interior do embrião; assegurar o intercâmbio de gases; e eliminar substâncias tóxicas derivadas do metabolismo proteico. Para atender estas necessidades são desenvolvidas uma série de membranas extrambrionárias que se vão expandindo progressivamente pelo interior do ovo. A dureza da casca e sua relativa impermeabilidade protege-o igualmente da intempérie terrestre. -/- Figura 23: Evolução das membranas extraembrionárias de galinha (3 e 10 dias de incubação). -/- Saco vitelino: o saco vitelino é a primeira membrana extraembrionária em formação. Aparece como consequência direta da gastrulação: as camadas germinativas que se formam ao nível do disco embrionário expandem-se progressivamente contornando o vitelo. Assim, as células provenientes da área opaca (equivalente ao trofoblasto dos mamíferos) migram sobre o vitelo, terminando quase por cobrir, o mesmo ocorre com o endoderma mais internamente, formando-se assim um saco bilaminar. Posteriormente, o mesoderma se interpõe entre ambos, progredindo igualmente no sentido distal, rodeando o endoderma e aderindo-se ao mesmo e ao equivalente de trofoblasto. Ao estabelecer-se o celoma, o saco é constituído pelo endoderma e folha esplâncnica do mesoderma lateral. Este mesoderma vai progredindo no sentido distal e se vasculariza profunda- mente; os vasos distais se anastomosam formando um anel vascular denominado seio terminal, que marca o limite do mesoderma em expansão. Assim, sobre o vitelo é distinguível um área distal não vascularizada (área vitelina) e uma área proximal vascularizada (área vasculosa) que vai ficando progressivamente maior. Ao sexto dia de incubação mais da metade da superfície do vitelo foi envolvido pelo mesoderma. Os nutrientes do vitelo são absorvidos e desdobrados a componentes mais simples por enzimas produzidas pelo endoderma, sendo incorporados aos vasos vitelinos que os veicularão até o coração, que os impulsionará a todo o embrião. Durante a fase embrionária (até ao sexto dia de incubação), o oxigênio do exterior chega até a área vasculosa por difusão, incorporando-se daqui ao embrião; além disso, durante a primeira semana, as alterações na composição e volume do vitelo fazem que se disponha flutuando sobre o albúmen, o que faz com que a área vasculosa fique em contato com a casca, favorecendo-se assim a respiração. O intestino primitivo se instaura a partir das porções mais proximais do saco vitelino à vez que o corpo é fechado (2º-3º dia). O saco vitelino vai regredindo à medida que se vão esgotando os nutrientes do vitelo que aloja. Pouco antes do nascimento é incorporado à cavidade corporal como divertículo vitelino que fica unido ao jejuno; o divertículo vitelino persiste até seis dias após o nascimento, constituindo uma fonte adicional de nutrientes. -/- Figura 24: Feto de galinho ao fim, perto de ser eclodido. -/- mnios: no segundo dia (-30 horas) de incubação se formam as dobras amnióticas na somatopleura extraembrionária, perto do disco embrionário. Progridem dorsalmente, terminando por convergir e fundir-se cerca de 72 horas de incubação, coincidindo com o fechamento corporal, assim sendo constituído o âmnios, que terminará perdendo todo o contato com o córion. A cavidade amniótica que limita está cheia de um líquido seroso que garante que o embrião seja desenvolvido em um meio aquoso; este líquido é secretado pelo âmnios, mas também composto por substâncias formadas pelos rins, cavidade oral e aparelho respiratório. Córion: após a formação do celoma e o estabelecimento e fusão das dobras amnióticas, a parte da somatopleura extraembrionária que fica mais periférica constitui o córion (também denominado serosa nas aves); permanece formada pela área opaca expandida e mesoderma somático. Progressivamente vai aderindo-se à membrana testácea interna deslocando o albúmen; sobre o dia 12 termina por cobrir toda a superfície interna da casca. Intervém na troca gasosa com o meio ambiente através dos poros da casca e na captação do cálcio desta. Alantóides: o alantóide inicia a sua formação no dia 3 de incubação. Cresce rapidamente, ocupando o espaço exocelômico, terminando por cobrir o âmnios e saco vitelino. Progressivamente, entre os dias 4 a 10, sua parte mais externa se funde com o córion, formando-se o alantocórion, membrana trilaminar que cobrirá a superfície interna da casca, aderindo-se à membrana testácea interna, cujo mesoderma (esplâncnico) se vasculariza intensamente. A partir do dia 7 substitui completamente a área vasculosa como órgão respiratório, sendo garantido o aumento gradual das necessidades de troca gasosa na fase fetal do desenvolvimento (desde o dia 8), de rápido crescimento. A capacidade de capilarização desta membrana é muito maior do que a do saco vitelino. Na cavidade alantóica acumula-se a urina produzida pelos rins, afastando os produtos tóxicos do embrião; a membrana também age sobre este fluido intervindo na manutenção do equilíbrio hídrico e mineral do embrião. -/- Figura 25: Formação do saco vitelino. Limite entre a área vascular e avascular. Seio terminal. -/- O albúmen perde água rapidamente e torna-se menos volumoso e mais viscoso, terminando por desaparecer progressivamente. A ligação do alantocórion à membrana testácea interna faz com que seja marginalizado para uma posição periférica, no polo agudo do ovo. Aqui, o alantocórion que o rodeia constitui o saco do albúmen. O albúmen é a principal fonte de água e proteínas. A água é incorporada ao vitelo, o que, ao tornar-se mais volumoso, provoca que, entre os dias 3 e 4, se rompa a membrana vitelina; apenas restos mortais devem permanecer entre o saco vitelino e o albúmen. Dentro do saco vitelino, a água se acumula principalmente sob o embrião -fluido subembrionário-; este fluido atinge o seu volume máximo (15 ml) no dia 6. As proteínas serão incorporadas principalmente a partir de no dia 12, seja através do saco vitelino, do saco do albúmen ou por ingestão de líquido amniótico, dada a comunicação seroamniótica que se estabelece. Na galinha, a eclosão ocorre aos 21 dias de incubação. REFERÊNCIAS BIBLIOGRÁFICAS -/- Anotações de aulas de Embriologia Básica, Prof. Dr. Edson João da Silva, UFRPE, 2021. BAZER, Fuller W. et al. Novel pathways for implantation and establishment and maintenance of pregnancy in mammals. MHR: Basic science of reproductive medicine, v. 16, n. 3, p. 135-152, 2009. CARTER, Anthony M. Evolution of placental function in mammals: the molecular basis of gas and nutrient transfer, hormone secretion, and immune responses. Physiological Reviews, 2012. CARTER, A. M.; ENDERS, A. C. Placentation in mammals: Definitive placenta, yolk sac, and paraplacenta. Theriogenology, v. 86, n. 1, p. 278-287, 2016. CONSTANTINESCU, G.M.; SCHATTEN, H. Comparative reproductive biology. Carlton: Blackwell Publishing, 2007. 402p. Avicultura: Formação do Ovo. Desenvolvimento Embrionário e Diferenciação Sexual nos Animais Domésticos. Disponível em:. Acesso em: Dezembro de 2021. Diferenciação e Determinação Sexual dos Animais. Fisiologia do Ciclo Estral dos Animais Domésticos. Emanuel Isaque Cordeiro da Silva, 2021. Manejo na Avicultura: Postura, Iluminação e Incubação dos Ovos. Transporte de Gametas, Fertilização e Segmentação. FERRER‐VAQUER, Anna; HADJANTONAKIS, Anna‐Katerina. Birth defects associated with perturbations in preimplantation, gastrulation, and axis extension: from conjoined twinning to caudal dysgenesis. Wiley Interdisciplinary Reviews: Developmental Biology, v. 2, n. 4, p. 427-442, 2013. GALINA, Carlos; VALENCIA, Javier. Reproducción de los animales domésticos. 2006. GEISERT, Rodney D.; SPENCER, Thomas E. Placentation in Mammals. Springer, 2021. GINTHER, O. J. Reproductive Biology of The mare: Basic and Applied Aspects. 2. ed. Cross Plains, Wisconsin: Equiservices, 1992. GUILLOMOT, Michel. Cellular interactions during implantation in domestic ruminants. Journal of Reproduction and Fertility-Supplements only, n. 49, p. 39-52, 1995. KLEIN, C.; TROEDSSON, M. H. T. Maternal recognition of pregnancy in the horse: a mystery still to be solved. Reproduction, Fertility and Development, v. 23, n. 8, p. 952-963, 2011. MIGLINO, Maria Angelica et al. The carnivore pregnancy: the development of the embryo and fetal membranes. Theriogenology, v. 66, n. 6-7, p. 1699-1702, 2006. MOFFETT, Ashley; LOKE, Charlie. Immunology of placentation in eutherian mammals. Nature Reviews Immunology, v. 6, n. 8, p. 584-594, 2006. PRETZER, S. D. Canine embryonic and fetal development: A review. Theriogenology, v. 70, n. 3, p. 300-303, 2008. SENGER, Phillip L. et al. Pathways to pregnancy and parturition. Current Conceptions, Inc., 1615 NE Eastgate Blvd., 2012. SOZEN, Berna; CAN, Alp; DEMIR, Necdet. Cell fate regulation during preimplantation development: a view of adhesion-linked molecular interactions. Developmental biology, v. 395, n. 1, p. 73-83, 2014. SPENCER, Thomas E. et al. Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses. Reproduction, fertility and development, v. 19, n. 1, p. 65-78, 2006. VERSTEGEN-ONCLIN, K.; VERSTEGEN, J. Endocrinology of pregnancy in the dog: a review. Theriogenology, v. 70, n. 3, p. 291-299, 2008. WOODING, Peter; BURTON, Graham. Comparative placentation: structures, functions and evolution. Springer Science & Business Media, 2008. FIXAÇÃO DO ASSUNTO -/- 1. Defina e diferencie os processos de desenvolvimento embrionário precoce, alonga- mento e gastrulação. -/- 2. O que é implantação? Caracterize as fases do processo de implantação. -/- 3. Qual a importância do acúmulo de líquido no interior do blastocele? Qual a importân- cia da eclosão do blastocisto? -/- 4. Caracterize os três tipos de implantação e, depois, explique e diferencie os meios de implantação nas fêmeas domésticas. -/- 5. Defina e caracterize os meios de reconhecimento materno da gestação (RMG) nos animais domésticos. -/- 6. O que diferencia o RMG em ruminantes e suínos? -/- 7. Qual o papel do estradiol no RMG em porcas? O que ocorre quando a porca não fica gestante? -/- 8. Explique o RMG em cães e gatos. -/- 9. Defina placentação e sua importância para a reprodução dos animais domésticos. -/- 10. Quais são as classificações da placentação? Classifique a placentação das fêmeas domésticas. -/- 11. Caracterize e diferencie o processo de placentação em fêmeas domésticas. -/- 12. Observe a figura e responda o que se pede:. (shrink)

A partir do século XIX, a teoria democrática foi desenvolvida com base no confronto entre duas doutrinas políticas: o liberalismo e o socialismo. O liberalismo é um projeto que defende as limitações dos poderes governamentais, buscando a proteção dos direitos econômicos, políticos, religiosos e intelectuais dos membros da sociedade. Ou seja, para os liberais o poder do Estado deve ser limitado, pois eles acreditam que a verdadeira liberdade depende da menor interferência possível do Estado e das leis nesses direitos. A (...) defesa do liberalismo tem como principal representante Benjamin Constant. Membro da Assembleia Nacional Francesa, escreveu a obra A liberdade dos antigos comparada com a dos modernos, na qual afirma que a liberdade dos modernos, que deve ser promovida e desenvolvida, é a liberdade individual na relação com o Estado (ou seja, as liberdades civis e políticas), enquanto a liberdade dos antigos, que se tornou impraticável, é a liberdade de participação direta na formação das leis.1 Outros autores como, como o francês Alexis de Tocqueville2 e o inglês John Stuart Mill3 , defenderam a ideia de que a única estrutura democrática compatível com o Estado liberal seria a democracia representativa. Uma passagem interessante para o nosso debate sobre a democracia é o princípio do dano, de Stuart Mill. Por esse princípio, cada indivíduo tem o direito de agir como quiser desde que suas ações não prejudiquem outras pessoas. Se a ação afeta diretamente apenas a pessoa que a está realizando, a sociedade em tese não tem o direito de intervir, mesmo que o indivíduo esteja prejudicando a si próprio. Contudo, se os indivíduos fizerem algo ruim para si mesmos ou para sua propriedade podem indiretamente prejudicar a coletividade, já que ninguém vive isolado, devendo por isso ser impedidos de fazê-lo. Stuart Mill isenta desse princípio aqueles que são incapazes de se governar. Em síntese, todo o processo de democratização, como se deu nos Estados liberais democráticos, consiste numa transformação mais quantitativa do que qualitativa do regime representativo. Ou seja, o avanço da democracia nesses regimes ocorre em duas direções: no alargamento gradual do direito do voto e na multiplicação dos órgãos representativos. Para a doutrina socialista, o sufrágio universal é apenas o ponto inicial do processo de democratização do Estado, enquanto para o liberalismo é o ponto de chegada. Alguns dos principais teóricos do socialismo, como Antonio Gramsci4 e Rosa Luxemburgo5 , afirmam que o aprofundamento do processo de democratização na perspectiva das doutrinas socialistas ocorre de dois modos: por meio da crítica à democracia representativa (e da retomada de alguns temas da democracia direta) e pela ampliação da da participação popular e do controle do poder por meio dos chamados “conselhos operários”. Em outras palavras, a diferença crucial entre a democracia dos conselhos e a democracia parlamentar é que a primeira reconhece ter havido um deslocamento dos centros de poder dos órgãos tradicionais do Estado para a grande empresa, na sociedade capitalista. Por isso, o controle que o cidadão pode exercer por meio dos canais tradicionais da democracia política não é suficiente para impedir os abusos de poder. Logo, o controle deve acontecer nos próprios lugares de produção, e seu protagonista é o trabalhador real, não o cidadão abstrato da democracia formal. Mais recentemente, na metade do século XX, surgiu a corrente pluralista. Os pluralistas, em particular Robert Dahl6 , cientista político estadunidense, não procuravam estabelecer uma definição abstrata e teórica acerca da democracia, mas, por meio da observação das experiências de sistemas políticos, estipularam alguns requisitos mínimos: funcionários eleitos, eleições livres justas e frequentes, liberdade de expressão, fontes de informação diversificadas, autonomia para associações e cidadania inclusiva. Com base nesses critérios são caracterizadas quatro estruturas de governo: hegemonias fechadas, que são regimes em que não há disputa de poder e a participação política é limitada; hegemonias inclusivas, regimes em que não há disputa de poder, mas ocorre participação política; oligarquias competitivas, regimes nos quais há disputa de poder, mas com limitada participação política; e poliarquias, regimes em que não há disputa de poder e participação política ampliada. Joseph Schumpeter (1883-1950), economista austríaco, criticou as teorias clássicas de democracia, especialmente na relação estabelecida entre a democracia e a soberania popular7 . Para o autor, a definição clássica de democracia supõe duas ficções incapazes de resistir a uma análise realista: a existência do bem comum e a universalidade da racionalidade dos indivíduos. Para Schumpeter, a unidade da vontade geral, que constituiria o bem comum, e a racionalidade dos indivíduos seriam mitos, porque, para ele, esses elementos se tornaram irracionais por não conseguirem definir coerentemente suas preferências diante da influência da propaganda e de outros métodos de persuasão. Dessa forma, Schumpeter rompe com a ideia de democracia como soberania popular para propô-la como método, um tipo de arranjo institucional (de governos) para alcançar decisões políticas. Assim, sugere a superação do impedimento provocado pela irracionalidade das massas, reduzindo sua participação na política ao ato da produção de governos (ato de votar). As atribuições político-administrativas ficariam a cargo das elites eleitas. Essa é uma postura polêmica, na medida em que propõe uma redução da participação popular. Contrário a essa visão, o cientista político canadense C. B. Macpherson8 , sustenta que a liberdade e o desenvolvimento individual só podem ser alcançados plenamente com a participação direta e contínua dos cidadãos na regulação da sociedade e do Estado. Macpherson defende uma transformação estruturada em um sistema que combine partidos competitivos e organizações de democracia direta, que criam uma base real para a existência da democracia participativa. Mas, para que esse modelo pudesse se desenvolver, seria necessário que os partidos políticos se democratizassem, com princípios e procedimentos de democracia direta, complementada e controlada por organizações geridas por pessoas comuns, em seus locais de trabalho e nas comunidades locais. Na teoria das elites, o poder político pertence ao restrito círculo de pessoas que toma e impõem decisões a todos os membros que tenha de recorrer, como ação radical, à força. Ainda na doutrina liberal, mas opondo-se ao pluralismo, existem os elitistas, que utilizam o termo “elite” como referência a grupos sociais superiores de vários tipos. O termo seria empregado no pensamento social e político somente no final do século XIX. Essas teorias sociológicas, propostas pelos pensadores Vilfredo Pareto (1848-1923), sociólogo e economista francês; Gaetano Mosca (1858-1941), cientista político italiano, e Robert Michels (1876-1936), sociólogo alemão radicado na Itália, defendem que em toda sociedade existe apenas uma minoria, que, por diversos motivos, vem a se tornar detentora do poder. Pareto afirmava que existe uma “circulação das elites”, ou seja, uma minoria de pessoas que se alternam no poder. Mosca justifica o poder das elites governamentais pelo fato de serem uma minoria articulada e organizada, enquanto os governos seriam uma classe numerosa, mas dividida e desorganizada. Ao estudar as formações partidárias, Michels destacou como a própria estrutura das organizações favorecia o surgimento das elites e sua longa permanência no poder. Nas palavras de Michels, essa estabilidade das elites no poder é a “lei de ferro das oligarquias”. Ao longo dos últimos séculos foram construídas diversas interpretações e teorias acerca dos objetivos e conteúdos da democracia. Na prática, a democracia pode ser um modelo de governo que amplia as capacidades de desenvolvimento social, político e econômico, com base em princípios de igualdade e cidadania, ou se tornar uma simples “regra” para formar governos que não priorizem necessariamente o atendimento das demandas sociais. REFERÊNCIAS BIBLIOGRÁFICAS CONSTANT, B. A liberdade dos antigos comparada à dos modernos. 1. ed. São Paulo: Atlas, 2015. DAHL, R. Poliarquia: participação e oposição. São Paulo: Edusp, 1987. ________. Um prefácio à teoria democrática. Rio de Janeiro: Jorge Zahar, 1989. LUXEMBURGO, R. Têxteis. Paris: Editions Socieles, 1982. MACPHERSON, C. B. A teoria política do individualismo possessivo, de Hobbes e Locke. Tradução de Nelson Dantas. Rio de Janeiro: Paz e Terra, 1979. MICHELS, R. Sociologia dos partidos políticos. Brasília: Ed. da UnB, 1982. MILL, J. S. Sobre a liberdade. Petrópolis: Vozes, 1991. SCHUMPETER, J. A. Capitalismo, socialismo e democracia. Rio de Janeiro: Jorge Zahar, 1984. SILVA, A. et. al. Sociologia em movimento. 2. ed. São Paulo: Moderna, 2016. TOCQUEVILLE, A. A democracia na América: leis e costumes. São Paulo: Martins Fontes, 1998. -/- . (shrink)

NUTRIÇÃO SOBRE AS FALHAS REPRODUTIVAS DOS BOVINOS -/- E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede -/- -/- FALHAS REPRODUTIVAS DE BOVINOS -/- INTRODUÇÃO -/- Os bovinos, assim como tantos outros mamíferos e demais espécies, podem sofrer distúrbios durante o ciclo reprodutivo. Transtornos, alterações ou patogenias afetam diretamente a saúde do sistema reprodutor desses animais. As causas podem ser individuais ou multifatoriais, de caráter parasitário, patogênico, climático, nutricional etc. As (...) causas de caráter parasitário podem ser controladas mediante a assepsia e profilaxia para a eliminação dos parasitas como carrapatos que vivem no mesmo habitat que o animal. As de caráter patogênico, como estão relacionadas à doenças, necessitam de especialistas na área, como o médico-veterinário para a avaliação, diagnóstico e tratamento por meio de práticas cirúrgicas ou na administração de fármacos. O fator clima pode ser controlado mediante o investimento em tecnologia e aquisição de equipamentos que possam manter a integridade e o bem-estar do animal, seja por ventiladores, exaustores, nebulizadores, aspersores, etc. Por fim, as de caráter nutricional podem ser prevenidas mediante a boa administração energética, proteica e mineral, além de uma boa qualidade de alimento volumoso ou concentrado que atenda e supra os requerimentos exigidos por cada categoria animal. Sendo assim, pode-se dividir as falhas reprodutivas dos machos bovinos relacionados à nutrição em energia, proteína, minerais e vitaminas. Antes disso, essas falhas estão relacionadas aos fatores de degeneração testicular e casos de hipospermia. -/- 17.1 Degeneração testicular e Hipospermia -/- Degeneração testicular é uma importante causa de infertilidade em machos de todas as espécies. Entre as causas, podem ser consideradas a elevação da temperatura testicular (por isso torna-se importante que a bolsa escrotal tenha um certo tamanho que permita aos testículos ficarem longe do corpo, uma vez que a temperatura corporal mataria os espermatozoides, sendo essencial os testículos ficarem “caídos” para que possam ter no mínimo 2-3 °C à mesmos do que a temperatura corporal), infecções, fatores nutricionais, lesões vasculares, lesões obstrutivas etc. O testículo com degeneração mostra diminuição de tamanho, fibrose, alterações na espermatogênese, aumento de esperma imaturo ou anormal e azoospermia em casos severos. -/- Em casos de lesão testicular com dano parcial sobre o epitélio germinal, apresenta-se uma menor taxa de formação e maturação das células espermáticas. O macho pode ser fértil, mas a condição de hipospermia levará à que, sob condições de estresse ou alta carga de fêmeas a cobrir, se apresentem falhas na fertilização. Ejaculados com características de hipospermia não podem ser congelados, logo não servem para a indústria do sêmen. -/- -/- Deficiências nutricionais retardam o início da puberdade e deprimem a produção e as características do sêmen. Os efeitos da má nutrição podem ser corrigidos em animais maduros, enquanto que é menos bem sucedido em animais jovens devido aos danos permanentes causados no epitélio germinal do testículo. (FRAZER, 2005; GORDON, 1996). Entre as principais limitantes de origem nutricional temos: -/- 17.2 Vitaminas -/- 17.2.1 Vitamina A -/- A deficiência de vitamina A e provitamina A (já que é essencial direta ou indiretamente para a função de todos os órgãos e particularmente para o crescimento e desenvolvimento dos epitélios) é necessária para a diferenciação celular, processo no qual se modificam as células não especializadas de modo que possam realizar funções específicas. Os órgãos reprodutores exigem retinol para que possam realizar o processo de espermatogênese normal nos machos e para prevenir a necrose placentária e a mortalidade fetal na fêmea. Carências de Vitamina A produzem: degeneração do epitélio germinal, baixa espermiogênese parcial ou total, cornificação do epitélio vaginal, irregularidades do estro, atrasos na concepção, abortos, crias fracas e/ou deficientes visuais (cegas) e uma degeneração da placenta e a retenção da mesma. A deficiência da vitamina A pode conduzir a uma degeneração dos tubos seminíferos nos bovinos jovens e deve-se ao fato da supressão da liberação de gonadotropinas hipofisárias e noutros casos, a espermatogênese é impedida e as funções das células de Sertoli e de Leydig são alteradas. A vitamina A não é sintetizada no organismo, o que leva a uma dependência direta do fornecimento dessa vitamina através dos alimentos que o criador têm na propriedade, seja forragens ou concentrados de ótima qualidade. -/- Essa vitamina é essencial para os animais e humanos, visto que participa de inúmeras funções metabólicas no corpo dos mesmos. Sendo assim, o criador deve saber das exigências vitamínicas do seu rebanho. Em bovinos de corte a exigência e a recomendação de fornecimento dessa vitamina está entre 2200 UI/kg de MS para animais em crescimento e engorda e para reprodutores recomenda-se níveis de 3900 UI/kg de MS. Já para bovinos leiteiros esses números são diferentes, de acordo com livros de nutrição de ruminantes, animais em crescimento e engorda devem consumir matéria seca com teores de 80 UI/kg de MS, já para reprodutores e animais adultos a quantidade recomendada e exigida é de 110 UI/kg de MS, isso diariamente. As forragens suprem bem a exigência de vitamina A dos animais, em especial o capim tifton e o tanzânia são os mais recomendados uma vez que possuem altos teores vitamínicos e minerais. As vias de suplementação dessa vitamina é através das forragens (mais acessível e barato), através da ração concentrada ou pela água e suplementação injetável. -/- 17.2.2 Vitamina E -/- A vitamina E é uma substância também conhecida como tocoferol, sendo sua forma mais ativa o alfa tocoferol. A vitamina E pertence ao grupo de vitaminas lipossolúveis amplamente distribuídas nos alimentos. -/- A sua principal função é descrita como um antioxidante natural, agindo como tal, a vitamina E evita a oxidação de constituintes celulares essenciais e/ou evita a formação de produtos tóxicos de oxidação, como os produtos de peroxidação formados a partir de ácidos graxos insaturados que foram detectados através de sua ausência. Essa vitamina é essencial para a reprodução normal em várias espécies de mamíferos. Ela ainda têm sido usada em clínicas reprodutivas de todo o mundo para o tratamento de abortos recorrentes e da infertilidade em ambos os sexos (CHAN, 2003). -/- -/- A deficiência da vitamina E influencia a maturação espermática e a degeneração do epitélio germinal dos túbulos seminíferos, já que ela os protege da oxidação evitando a deterioração da peroxidase sobre os fosfolipídios poli-insaturados da membrana espermática (PITA RODRÍGUEZ, 1997). A deficiência dessa também evita o crescimento anormal. Na ausência de vitamina E, a quantidade de gorduras insaturadas dentro das células diminuem, causando anomalias estruturais e funcionais das organelas mitocondriais, lisossomos e até mesmo na membrana celular, se essa falta de vitamina E no adulto tornar-se acentuada ocorrerá a degeneração precoce do epitélio germinal, o que afeta, em primeiro lugar, as células mais evoluídas: os espermatozoides, cuja mobilidade se perde e sua formação torne-se cada vez mais rara, até chegar ao nível de esterilidade completa. -/- As exigências dos bovinos de corte quanto a vitamina em questão é de 15 – 60 UI/kg de MS diárias para animais em crescimento e engorda. Já para bovinos leiteiros, essa exigência é muito menor chegando a 0,8 UI/kg de peso vivo (PV) para animais em crescimento e engorda e para animais adultos e reprodutores cerca de 1,6 UI/kg de PV diários. Os alimentos, assim como as vias de suplementação ideais, são os mesmos mencionados no tópico acerca da vitamina A. -/- 17.3 Proteínas -/- O efeito do excesso de proteína da dieta na reprodução é complexo. Os excessos de proteína podem também ter um efeito negativo na reprodução. Alguns efeitos foram demonstrados para explicar o pobre desempenho reprodutivo que algumas vezes é observado em dietas com excessivos níveis de proteína: Podem apresentar-se altos níveis de ureia no sangue, o que possui efeito tóxico sobre os espermatozoides, óvulos, e o embrião em desenvolvimento (WATTIAUX, 1990), igualmente, apresenta-se um desequilíbrio energético que em casos severos bloqueia a liberação de LH produzindo alteração na maturação espermática nas células de Leyding. -/- As proteínas são importantes para todo o funcionamento normal e funções fisiológicas e metabólicas dos animais e do homem. Logo, a tabela 1 traz os níveis recomendados e exigências de bovinos de corte de diferentes categorias para que se possa prevenir e/ou combater as possíveis degenerações testiculares bem como a hipospermia, trazendo os requerimentos de bovinos leiteiros jovens o que é mais ideal para combater previamente esses distúrbios que afetam diretamente a função reprodutiva e o desemprenho dos animais. -/- Tabela 1: Exigências de proteína metabolizável (PM) e proteína bruta (PB), para diferentes categorias de bovinos de corte -/- BAIXE O PDF E VISUALIZE A TABELA -/- Para os bovinos leiteiros jovens, os níveis de PB presente na dieta dos animais entre 150 e 400 kg de PV podem ser entre 12 e 22%, o que é ideal para a prevenção de degenerações, atraso à puberdade ou qualquer anormalidade que afete o desempenho dos animais. -/- Os alimentos mais proteicos são os de origem animal, porém não se pode ofertá-los completamente e diretamente aos animais, isto é, deve-se misturá-los a outros ingredientes; logo, o tipo e a quantidade de proteína depende dos ingredientes, do método de alimentação e do potencial produtivo e genético dos animais. -/- 17.4 Minerais -/- 17.4.1 Manganês (Mn) -/- O manganês é um componente de várias enzimas e essencial para a estrutura óssea normal. Quando a alimentação é deficiente em Mn por algumas semanas, o corpo parece conservar este mineral de forma eficaz. -/- Numa dieta média, cerca de 45% do mineral ingerido é absorvido. A absorção pode ser diminuída com o consumo de quantidades excessivas de Ca, P ou Fe. Após a absorção, o Mn liga-se à sua proteína transportadora e é conhecido como transmanganina. Os ossos, e em menor quantidade o fígado, músculos, e pele servem como locais de armazenamento desse mineral. -/- O Mn está envolvido na função pancreática e na utilização correta da glicose, sendo também um interveniente ativo na produção de tiroxina e de hormonas sexuais. Tem importância na produção do colesterol e no metabolismo de gorduras. -/- O Mn é um mineral de grande afinidade com o aparelho reprodutor. A deficiência desse elemento produz uma diminuição da fertilidade, atraso no desenvolvimento testicular e diminuição da espermatogênese. Se houver atrofia dos testículos, a produção de espermatozoides será reduzida e, portanto, a fertilidade será afetada. -/- A quantidade de 13 mg de Mn por kg de MS é suficiente para a obtenção de um crescimento adequado, mas para um crescimento testicular ideal e constante é necessário um mínimo de 16 mg de Mn por kg de MS. -/- Para uma boa suplementação que atenda às necessidades do gado de corte e leite, o nível ideal de Mn presente na MS em mg/kg deve estar entre 12 – 18 para os bovinos leiteiros e entre 20 – 50 para o gado de corte, tendo como recomendação ideal cerca de 40 mg/kg de MS diários para ambos. Esse mineral pode estar presente tanto na água quanto nas plantas presentes no pasto, portanto a suplementação natural é a melhor escolha, caso necessário a suplementação artificial através da ração no cocho ou do sistema SMI é recomendada. -/- 17.4.2 Iodo (I) -/- A deficiência de I também ocasionar dificuldades reprodutivas e hipospermia. Só a captação da tiroide responde à TSH, e somente a glândula endócrina tiroide incorpora esse elemento nos hormônios que são por ela elaborados. Assim, mais de 90% do iodo do organismo é encontrado nas glândulas tireóideas, principalmente como iodo orgânico. Este grande acúmulo de I na glândula é trocado muito lentamente, cerca de 1% por dia. -/- O I entra no organismo via oral e sob a forma de íon iodeto, absorvendo-se muito facilmente desde o aparelho digestivo e passando rapidamente à corrente circulatória e, posteriormente à glândula tiroide (ALBARRACÍN, 2005) onde tem que vencer um gradiente de concentração de 1 a 20; todavia, dada a afinidade entre essa glândula e o iodo, não existe nenhum problema na organização. Na célula folicular, através da ação da peroxidase, converte-se em I molecular que passa para o coloide para se ligar à tiroglobulina e formar as hormonas tireóideas. -/- O I pode atuar sobre o aparelho genital diretamente ou através da hipófise. A tiroidectomia reduz a produção espermática, por sua vez a tiroxina exótica pode restaurá-la. Essa última, administrada dentro de seus limites fisiológicos, aumenta a produção espermática ao incrementar o metabolismo geral. Talvez, o mecanismo mais aceito para atingir esta função fisiológica seja a regulação do consumo de oxigênio pelas células espermáticas. -/- O I pode ser fornecido em quantidades entre 0,2 e 1,0 mg/kg de MS para todas as categorias animais e sem que o produtor possa se preocupar. O I, que é de suma importância, encontra-se na água e nos vegetais, porém pode ser incrementado via alimentação concentrada ou através da injeção mineral direta no animal. -/- 17.5 Energia -/- A disponibilidade de energia está diretamente relacionada com o padrão normal de pulsatilidade do LH. No caso do balanço energético negativo (BEN), verifica-se um rápido aumento da utilização de glicose, resultando em hipoglicemia e, por conseguinte, hipoinsulinemia que, como se sabe, conduz rapidamente a uma lipólise com maior disponibilidade de ácidos para oxidação. Por sua vez, a síntese de colesterol precursor de esteroides sexuais é diminuída. A alteração da relação estrogênios- androgênios no macho causa uma expressão pobre da libido ou desejo sexual. -/- No touro a subnutrição afeta intensamente a função secretora das glândulas acessórias, provocando uma diminuição de 30 a 60% nas concentrações de frutose e ácido láctico do esperma. A subnutrição afeta, sobretudo, a atividade androgênica e a espermatogênese. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- BARRENHO, Gonçalo José Pinheiro. Nutrição e fertilidade em bovinos de leite. 2016. Dissertação de Mestrado. Universidade de Évora. -/- BERCHIELLI, Telma Teresinha; PIRES, Alexandre Vaz; OLIVEIRA, SG de. Nutrição de ruminantes. Jaboticabal: funep, 2006. -/- BICUDO, S. D.; SIQUEIRA, J. B.; MEIRA, C. Patologias do sistema reprodutor de touros. Biológico, São Paulo, v. 69, n. 2, p. 43-48, 2007. -/- BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. -/- BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. -/- CHAN, Willie Hing Chang. Uso de Tamoxifeno y Vitamina E en Pacientes con Varicocele. 2003. Tese de Doutorado em Urologia. Universidad de Granada, España. -/- DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. -/- DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. -/- DIAS, Juliano Cesar et al. Alguns aspectos da interação nutrição-reprodução em bovinos: energia, proteína, minerais e vitaminas. PUBVET, v. 4, p. Art. 738-743, 2010. -/- FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. -/- GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. -/- MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. -/- MAGGIONI, Daniele et al. Efeito da nutrição sobre a reprodução de ruminantes: uma revisão. PUBVET, v. 2, n. 11, 2008. -/- NATIONAL RESEARCH COUNCIL et al. NRC. Nutrient requirements of domestic animals. Nutrient requirements of beef cattle. Washington, DC: National Academy Science, 1996. -/- NICODEMO, M. L. F.; SERENO, J. R. B.; AMARAL, T. B. Minerais na eficiência reprodutiva de bovinos. Embrapa Pecuária Sudeste-Documentos (INFOTECA-E), 2008. -/- PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. -/- PITA RODRÍGUEZ, Gisela. Funciones de la vitamina E en la nutrición humana. Rev. cuba. aliment. nutr, v. 11, n. 1, p. 46-57, 1997. -/- RADOSTITS, Otto M. et al. (Ed.). Veterinary Medicine E-Book: A textbook of the diseases of cattle, horses, sheep, pigs and goats. Elsevier Health Sciences, 2006. -/- SANTOS, José Eduardo Portela. Efeitos da nutrição na reprodução bovina. In: Congresso Brasileiro de Raças Zebuínas. 1998. p. 24-75. -/- SARTORI, Roberto; GUARDIEIRO, Monique Mendes. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. -/- SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. -/- TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. -/- WATTIAUX, Michel Andre. Reproduction and nutrition. Babcock Institute for International Dairy Research and Development, Madison: University of Wisconsin, 1995. (shrink)

Perhaps the topic of acceptable risk never had a sexier and more succinct introduction than the one Edward Norton, playing an automobile company executive, gave it in Fight Club: “Take the number of vehicles in the field (A), multiply it by the probable rate of failure (B), and multiply the result by the average out of court settlement (C). A*B*C=X. If X is less than the cost of the recall, we don’t do one.” Of course, this dystopic scene also gets (...) to the heart of the issue in another way: acceptable risk deals with mathematical calculations about the value of life, injury, and emotional wreckage, making calculation a difficult matter ethically, politically, and economically. This entry will explore the history of this idea, focusing on its development alongside statistics into its wide importance today. (shrink)

This article takes issue with two prominent views in the current debate around epistemic partiality in friendship. Strong views of epistemic partiality hold that friendship may require biased beliefs in direct conflict with epistemic norms. Weak views hold that friendship may place normative expectations on belief formation but in a manner that does not violate these norms. It is argued that neither view succeeds in explaining the relationship between epistemic norms and friendship norms. Weak views inadvertently endorse a form of (...) motivated reasoning, failing to resolve the normative clash they seek to avoid. Strong views turn out to be incoherent once we consider the question of whether the requirement to form an epistemically partial belief is independent of whether the belief in question would be true. It is then argued that an epistemology of friendship should recognise the special role that understanding plays in friendship. On this view, friendship normatively requires understanding the truth about our friends. This entails that epistemic partiality, far from being a requirement, is in fact at odds with good friendship. (shrink)

Review of Felice C. Frankel's "The visual elements—design: a handbook for communicating science and engineering.".

INTRODUCTION THE PROBLEM OF THE BEING OF THE EGO AND THE FUNDAMENTAL PRESUPPOSITIONS OF ONTOLOGY "Mit dem cogito sum beansprucht Descartes, der Philosophic ...

My interest lies in offering a phenomenological perspective on how noise is experienced, with particular attention to what may be common to different sorts of noise phenomena. As a counterpoint to the notion that noise is an empty or constructed notion, I argue for two desiderata of a phenomenological account of noise; accommodating a plurality of noise experiences, on the one hand, and clarifying their specific phenomenal character, on the other. I then pursue these desiderata by turning to an examination (...) of some contemporary views of perception that have implications for how the phenomenal character of perceptual noise in particular is to be understood; an epistemic misfire view and a sensory misfire view. After clarifying each and its appeal, I convey concerns about the one and the other. I propose a third alternative for further exploration - a perceptual disjoint view - and point to how it ought to explored. On the premise that there is something like a unity of consciousness or experience, I lay out the idea that there may then be many forms of 'disunities' of experience. From an analysis of the latter, I suggest, one may account for many different types of experiences of noise, though with a common ‘phenomenal’ thread running through them. (shrink)

In this paper I take up the question of the nature of the doxastic attitudes we entertain while inquiring into some matter. Relying on a distinction between two stages of open inquiry, I urge to acknowledge the existence of a distinctive attitude of cognitive inclination towards a proposition qua answer to the question one is inquiring into. I call this attitude “hypothesis”. Hypothesis, I argue, is a sui generis doxastic attitude which differs, both functionally and normatively, from suspended judgement, full (...) belief, credences, and acceptance. In closing, I point to the epistemological significance of hypothesis. More specifically, I contend that holding an attitude of hypothesis enables us to respond rationally to peer disagreement, and I suggest that such an attitude offers a suitable articulation of the view, originally put forward by Philip Kitcher, that cognitive diversity in inquiry has epistemic benefits. (shrink)

This paper tackles the problem of defining what a cognitive expert is. Starting from a shared intuition that the definition of an expert depends upon the conceptual function of expertise, I shed light on two main approaches to the notion of an expert: according to novice-oriented accounts of expertise, experts need to provide laypeople with information they lack in some domain; whereas, according to research-oriented accounts, experts need to contribute to the epistemic progress of their discipline. In this paper, I (...) defend the thesis that cognitive experts should be identified by their ability to perform the latter function rather than the former, as novice-oriented accounts, unlike research-oriented ones, fail to comply with the rules of a functionalist approach to expertise. (shrink)

To study (un)conscious perception and test hypotheses about consciousness, researchers need procedures for determining whether subjects consciously perceive stimuli or not. This article is an introduction to a family of procedures called ‘confidence-based procedures’, which consist in interpreting metacognitive indicators as indicators of consciousness. I assess the validity and accuracy of these procedures, and answer a series of common objections to their use in consciousness research. I conclude that confidence-based procedures are valid for assessing consciousness, and, in most cases, accurate (...) enough for our practical and scientific purposes. (shrink)

Studying consciousness requires contrasting conscious and unconscious perception. While many studies have reported unconscious perceptual effects, recent work has questioned whether such effects are genuinely unconscious, or whether they are due to weak conscious perception. Some philosophers and psychologists have reacted by denying that there is such a thing as unconscious perception, or by holding that unconscious perception has been previously overestimated. This article has two parts. In the first part, I argue that the most significant attack on unconscious perception (...) commits the criterion content fallacy: the fallacy of interpreting evidence that observers were conscious of something as evidence that they were conscious of the task-relevant features of the stimuli. In the second part, I contend that the criterion content fallacy is prevalent in consciousness research. For this reason, I hold that if unconscious perception exists, scientists studying consciousness could routinely underestimate it. I conclude with methodological recommendations for moving the debate forward. (shrink)

Despite contemporary moral philosophers' renewed attention to the moral significance of emotions, the attitudinal repertoire with which they equip the mature moral agent remains stunted. One attitude moral philosophers neglect (if not disown) is contempt. While acknowledging the nastiness of contempt, I here correct the neglect by providing an account of the moral psychology of contempt. In the process, I defend the moral propriety of certain tokens of properly person-focused contempt against some prominent objections -- among them, objections stemming from (...) Kantian worries that contempt is incompatible with the respect we owe to persons as such. (shrink)

Tradition has it that first-person thought is somehow special. It is also commonplace to maintain that the first-person concept obeys a rule of reference to the effect that any token first-person thought is about the thinker of that thought. Following Annalisa Coliva and, more recently, Santiago Echeverri, I take the specialness claim to be the claim that thinking a first-person thought comes with a certain guarantee of its pattern of reference. Echeverri maintains that such a guarantee is explained by a (...) fairly flatfooted interpretation of the thinker-reflexive rule. I argue, however, that the explanatory aspirations of the thinker-reflexive rule are fulfilled only if we accept an epistemically loaded gloss on the notion of a thinker of a thought featuring the rule. That gloss is unpacked in terms of the subject’s ability to be acquainted with the phenomenal character of their thoughts. (shrink)

Notes prises par Jacques Lagrange lors du cours d'anthropologie donné par Michel Foucault en 1954-1955 à l'École Normale Supérieure.

“Wild Wise Weird” is an extraordinary collection of short stories that offers a delightful window into Vietnamese culture through the quirky and thought-provoking adventures of Kingfisher, the clever protagonist from the bird village. Vuong Quan Hoang masterfully weaves humor, satire, and social commentary into tales that are both entertaining and deeply reflective.

The starting point of this paper is an argument to the conclusion that the definition of metaphysical possibility in terms of correct conceivability, conceivability informed by knowledge of relevant essences, found in Rosen (2006) is equivalent to a version of the essentialist definition of metaphysical necessity. This argument appears to show that correct conceivability is a notion of conceivability by name only and is therefore of no interest to epistemologists of modality. In this paper, I present the equivalence argument, explain (...) the idealizing assumptions involved in it and sketch a version of the conceivability approach which weakens these assumptions in order to show that the notion of correct conceivability can still play a specific limited role in the epistemology of modality. (shrink)

Permissivism is the view that, sometimes, there is more than one doxastic attitude that is perfectly rationalised by the evidence. Impermissivism is the denial of Permissivism. Several philosophers, with the aim to defend either Impermissivism or Permissivism, have recently discussed the value of (im)permissive rationality. This paper focuses on one kind of value-conferring considerations, stemming from the so-called “truth-connection” enjoyed by rational doxastic attitudes. The paper vindicates the truth-connected value of permissive rationality by pursuing a novel strategy which rests on (...) two main planks: first, there is a distinction between a fine-grained and a coarse-grained type-individuation of belief-forming methods. Secondly, different kinds of decision-theoretic reasoning, i.e. expected-accuracy reasoning and accuracy-domination reasoning, must be paired with a fine-grained and a coarse-grained type-individuation of methods, respectively. I argue that while the first pair is wholly irrelevant to the question of the truth-connection, the second affords the means to a permissivist explanation of the truth-connected value of rationality. (shrink)

Opponents to consciousness in fish argue that fish do not feel pain because they do not have a neocortex, which is a necessary condition for feeling pain. A common counter-argument appeals to the multiple realizability of pain: while a neocortex might be necessary for feeling pain in humans, pain might be realized differently in fish. This paper argues, first, that it is impossible to find a criterion allowing us to demarcate between plausible and implausible cases of multiple realization of pain (...) without running into a circular argument. Second, opponents to consciousness in fish cannot be provided with reasons to believe in the multiple realizability of pain. I conclude that the debate on the existence of pain in fish is impossible to settle by relying on the multiple realization argument. (shrink)

Francis Sparshott introduced the term ‘remote art’ in his 1982 presidential address to the American Society for Aesthetics. The concept has not drawn much notice since—although individual remote arts, such as palaeolithic art and the artistic practices of subaltern cultures, have enjoyed their fair share of attention from aestheticians. This paper explores what unites some artistic practices under the banner of remote art, arguing that remoteness is primarily a matter of some audience’s epistemic distance from a work’s context of creation. (...) I introduce palaeoart—the depiction of extinct prehistoric fauna and flora, especially from the Mesozoic—as a paradigmatic case of remote art, showing that its remoteness is secured both by the deceptively rich cognitive load required for its creation and appreciation, and by its existence at the margins of the institutional artworld, which ensures that this cognitive loading is largely obscured. Too often, remote art is not just inscrutable, it is invisible to us. (shrink)

Poetry evokes mental imagery in its readers. But how is mental imagery precisely related to poetry? This article provides a systematic treatment. It clarifies two roles of mental imagery in relation to poetry—as an effect generated by poetry and as an efficient means for understanding and appreciating poetry. The article also relates mental imagery to the discussion on the ‘heresy of paraphrase’. It argues against the orthodox view that the imagistic effects of poetry cannot be captured by prosaic paraphrase, but (...) points to features of poetry that can shape aspects of mental imagery that are liable to be lost in paraphrase. (shrink)